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Current Neuro-Oncology




Volume 26 Number 8
30 April 2024




Home > Publications > Current Neuro-Oncology > Volume 26, Year 2024 > Number 8, 30 April






Lowenstein PR, Varela ML, Castro MG.
Three recent breakthroughs in CAR T cells for the treatment of glioblastoma: Is it the light at the end of the tunnel?
Mol Ther. 2024 Apr 16:S1525-0016(24)00235-1. doi: 10.1016/j.ymthe.2024.04.018. PMID: 38631354. Comment˰ ˍ
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-Choi BD, Gerstner ER, Frigault MJ, Leick MB, Mount CW, Balaj L, Nikiforow S, Carter BS, Curry WT, Gallagher K, Maus MV.
Intraventricular CARv3-TEAM-E T Cells in Recurrent Glioblastoma.
N Engl J Med. 2024 Mar 13;390(14):1290-1298. doi: 10.1056/NEJMoa2314390. PMID: 38477966. Interventional study. ˍ


-Bagley SJ, Logun M, Fraietta JA, Wang X, Desai AS, Bagley LJ, Nabavizadeh A, Jarocha D, Martins R, Maloney E, Lledo L, Stein C, Marshall A, Leskowitz R, Jadlowsky JK, Christensen S, Oner BS, Plesa G, Brennan A, Gonzalez V, Chen F, Sun Y, Gladney W, Barrett D, Nasrallah MP, Hwang WT, Ming GL, Song H, Siegel DL, June CH, Hexner EO, Binder ZA, O'Rourke DM.
Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results.
Nat Med. 2024 Mar 13. doi: 10.1038/s41591-024-02893-z. PMID: 38480922. Interventional study˰ ˍ


-Brown CE, Hibbard JC, Alizadeh D, Blanchard MS, Natri HM, Wang D, Ostberg JR, Aguilar B, Wagner JR, Paul JA, Starr R, Wong RA, Chen W, Shulkin N, Aftabizadeh M, Filippov A, Chaudhry A, Ressler JA, Kilpatrick J, Myers-McNamara P, Chen M, Wang LD, Rockne RC, Georges J, Portnow J, Barish ME, D'Apuzzo M, Banovich NE, Forman SJ, Badie B.
Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial.
Nat Med. 2024 Mar 7. doi: 10.1038/s41591-024-02875-1. PMID: 38454126. Interventional study. ˍ




Okon II, Musharaf I, Chaurasia B, Qadri HM, Kankam SB, Lucero-Prisno DE 3rd.
Tuning in: musical resilience in awake craniotomy for brain tumor resection.
Neurosurg Rev. 2024 Apr 16;47(1):157. doi: 10.1007/s10143-024-02385-1. PMID: 38622378. Correspondence˰ ˍ




Zhu N, Chen S, Jin Y, Wang M, Fang L, Xue L, Hua D, Zhang Z, Jia M, Hao M, Zhang C.
Enhancing Glioblastoma Immunotherapy with Integrated Chimeric Antigen Receptor T Cells through the Re-Education of Tumor-Associated Microglia and Macrophages.
ACS Nano. 2024 Apr 16. doi: 10.1021/acsnano.4c00050. PMID: 38626338. Laboratory investigation˰ ˍ




*Alhaj AK, Burhamah T, Mohammad F, Almutawa M, Dashti F, Almurshed M, Behzad S, Snuderl M, Hasan A.
Are the Radiological and Molecular Features of Pediatric Medulloblastomas Valuable Prognostic Indicators? A 10-year Retrospective Review in the Middle East.
World Neurosurg. 2024 Apr 17:S1878-8750(24)00620-X. doi: 10.1016/j.wneu.2024.04.057. PMID: 38636638. Observational study. ˍ




Gately L, Mesía C, Sepúlveda JM, Del Barco S, Pineda E, Gironés R, Fuster J, Dumas M, Gill S, Navarro LM, Herrero A, Dowling A, de Las Peñas R, Vaz MA, Alonso M, Lwin Z, Harrup R, Peralta S, Long A, Perez-Segura P, Ahern E, Garate CO, Wong M, Campbell R, Cuff K, Jennens R, Gallego O, Underhill C, Martinez-Garcia M, Covela M, Cooper A, Brown S, Rosenthal M, Torres J, Collins IM, Gibbs P, Balana C.
Exploring management and outcomes of elderly patients with glioblastoma using data from two randomised trials (GEINO1401/EX-TEM).
J Neurooncol. 2024 Apr 17. doi: 10.1007/s11060-024-04668-5. PMID: 38630385. Observational study˰ ˍ




Dağdelen D, Zincir H.
Effects of dependent care theory-based post-surgical home care intervention on self-care, symptoms, and caregiver burden in patients with primary brain tumor and their caregivers: a randomized controlled trial.
Support Care Cancer. 2024 Apr 18;32(5):296. doi: 10.1007/s00520-024-08488-1. PMID: 38635060. Interventional study. ˍ




Low JCM, Cao J, Hesse F, Wright AJ, Tsyben A, Alshamleh I, Mair R, Brindle KM.
Deuterium metabolic imaging differentiates glioblastoma metabolic subtypes and detects early response to chemoradiotherapy.
Cancer Res. 2024 Apr 18. doi: 10.1158/0008-5472.CAN-23-2552. PMID: 38635885. Laboratory investigation. ˍ




Rolling CC, Mohme M, Bokemeyer C, Westphal M, Riethdorf S, Lamszus K, Pantel K, Klingler F, Langer F.
Circulating Tumor Cells and Thromboembolic Events in Patients with Glioblastoma.
Hamostaseologie. 2024 Apr 18. doi: 10.1055/a-2251-6766. PMID: 38636546. Observational study˰ ˍ




Tobochnik S, Regan MS, Dorotan MKC, Reich D, Lapinskas E, Hossain MA, Stopka S, Santagata S, Murphy MM, Arnaout O, Bi WL, Antonio Chiocca E, Golby AJ, Mooney MA, Smith TR, Ligon KL, Wen PY, Agar NYR, Lee JW.
Pilot trial of perampanel on peritumoral hyperexcitability and clinical outcomes in newly diagnosed high-grade glioma.
medRxiv [Preprint]. 2024 Apr 18:2024.04.11.24305666. doi: 10.1101/2024.04.11.24305666. PMID: 38645003. Interventional study. ˍ




*Oztep Eskici S, Yilmaz EB.
Prognostic significance of systemic inflammatory parameters in high-grade glial tumor patients: Two center experience.
Medicine (Baltimore). 2024 Apr 19;103(16):e37726. doi: 10.1097/MD.0000000000037726. PMID: 38640334. Observational study. ˍ




Zinsz A, Pouget C, Rech F, Taillandier L, Blonski M, Amlal S, Imbert L, Zaragori T, Verger A.
The role of [18 F]FDOPA PET as an adjunct to conventional MRI in the diagnosis of aggressive glial lesions.
Eur J Nucl Med Mol Imaging. 2024 Apr 19. doi: 10.1007/s00259-024-06720-y. PMID: 38637354. Observational study˰ ˍ




Reynolds JA, Pecorari IL, Ledet A, Agarwal V.
High-Grade Glioma Recurrence Is Delayed in Hispanic Patients despite Severe Social Vulnerability: A Retrospective Cohort Study.
Cancers (Basel). 2024 Apr 20;16(8):1579. doi: 10.3390/cancers16081579. PMID: 38672661. Observational study. ˍ




Choi YY, Lee M, Kim EH, Lee JE, Jung I, Cheong JH.
Risk of Subsequent Primary Cancers Among Adult-Onset 5-Year Cancer Survivors in South Korea: Retrospective Cohort Study.
JMIR Public Health Surveill. 2024 Apr 21;10:e48380. doi: 10.2196/48380. PMID: 38717807. Observational study. ˍ




Lindsay HB, Scheurer ME, Allam AK, Lucas BJ, McGovern SL, Chintagumpala M, Paulino AC.
Late-onset lymphopenia during radiation is associated with an increased risk of tumor recurrence in newly diagnosed pediatric medulloblastoma.
Pediatr Blood Cancer. 2024 Apr 21:e31022. doi: 10.1002/pbc.31022. PMID: 38644606. Observational study˰ ˍ




Liu C, Kuang S, Huang T, Wu J, Zhang L, Gong X.
Radiotherapy plus temozolomide with or without anlotinib in H3K27M-mutant diffuse midline glioma: A retrospective cohort study.
CNS Neurosci Ther. 2024 Apr 21;30(4):e14730. doi: 10.1111/cns.14730. PMID: 38644565. Observational study. ˍ




Bruhn H, Tavelin B, Rosenlund L, Henriksson R.
Do presenting symptoms predict treatment decisions and survival in glioblastoma? Real-world data from 1458 patients in the Swedish brain tumor registry.
Neurooncol Pract. 2024 Apr 23;11(5):652-659. doi: 10.1093/nop/npae036. PMID: 39279780. Observational study. ˍ




McKean WB, Yang J, Boucher K, Shrieve DC, Suneja G, Salzman K, Jensen R, Colman H, Cohen AL.
D-TERMINED, a phase 1 trial in newly diagnosed high-grade glioma with temozolomide, radiation, and minocycline followed by adjuvant minocycline/temozolomide.
Neurooncol Adv. 2024 Apr 23;6(1):vdae063. doi: 10.1093/noajnl/vdae063. PMID: 38800698. Interventional study. ˍ




Okamoto T, Mizuta R, Takahashi Y, Otani Y, Sasaki E, Horio Y, Kuroda H, Matsushita H, Date I, Hashimoto N, Masago K.
Genomic landscape of glioblastoma without IDH somatic mutation in 42 cases: a comprehensive analysis using RNA sequencing data.
J Neurooncol. 2024 Apr 23. doi: 10.1007/s11060-024-04628-z. PMID: 38653957. Laboratory investigation˰ ˍ




Takano S, Tomita N, Kuno M, Niwa M, Torii A, Takaoka T, Kita N, Okazaki D, Yamamoto S, Kawai T, Sugie C, Ogawa Y, Matsumoto K, Uchiyama K, Otsuka S, Matsui T, Miyakawa A, Mizuno T, Iida M, Tanikawa M, Mase M, Hiwatashi A.
Simultaneous boost radiotherapy versus conventional dose radiotherapy for patients with newly diagnosed glioblastoma: a multi-institutional analysis.
Sci Rep. 2024 Apr 23;14(1):9283. doi: 10.1038/s41598-024-60154-y. PMID: 38654028. Observational study. ˍ




Poklepovic AS, Shah P, Tombes MB, Shrader E, Bandyopadhyay D, Deng X, Roberts CH, Ryan AA, Hudson D, Sankala H, Kmieciak M, Dent P, Malkin MG.
Phase 2 Study of Sorafenib, Valproic Acid, and Sildenafil in the Treatment of Recurrent High-Grade Glioma.
medRxiv [Preprint]. 2024 Apr 24:2024.04.23.24304634. doi: 10.1101/2024.04.23.24304634. PMID: 38712133. Interventional study. ˍ




Zhou S, Wu S, Li Z, Wang X.
Construction and Validation of Nomograms for Predicting Overall Survival and Cancer-Specific Survival in Patients with Primary Anaplastic Oligodendroglioma.
World Neurosurg. 2024 Apr 25:S1878-8750(24)00684-3. doi: 10.1016/j.wneu.2024.04.111. PMID: 38677647. Observational study˰ ˍ




Doron O, Wong T, Ablyazova F, Singha S, Cavallaro J, Ben-Shalom N, D'Amico RS, Harshan M, McKeown A, Zlochower A, Langer DJ, Boockvar JA.
Results from a first-in-human phase i safety trial to evaluate the use of a vascularized pericranial/temporoparietal fascial flap to line the resection cavity following resection of newly diagnosed glioblastoma.
J Neurooncol. 2024 Apr 26. doi: 10.1007/s11060-024-04647-w. PMID: 38664311. Interventional study. ˍ




Engelhardt M, Schneider H, Reuther J, Grittner U, Vajkoczy P, Picht T, Rosenstock T.
Low-frequency repetitive transcranial magnetic stimulation in patients with motor deficits after brain tumor resection: a randomized, double-blind, sham-controlled trial.
Front Oncol. 2024 Apr 26;14:1368924. doi: 10.3389/fonc.2024.1368924. PMID: 38737898. Interventional study. ˍ




McDonald AM, Murdaugh DL, Heinzman KA, Cardan RA, Jacob J, Fiveash JB, Nabors LB, Cooper CA, Hoyle JM, Milner D, Cardenas CE.
Longitudinal brain volumetrics in glioma survivors.
J Neurosurg. 2024 Apr 26:1-8. doi: 10.3171/2024.1.JNS231980. PMID: 38669700. Observational study˰ ˍ




Xing Z, Wang C, Yang W, She D, Yang X, Cao D.
Predicting glioblastoma recurrence using multiparametric MR imaging of non-enhancing peritumoral regions at baseline.
Heliyon. 2024 Apr 26;10(9):e30411. doi: 10.1016/j.heliyon.2024.e30411. PMID: 38711642. Observational study. ˍ




*Guo E, Gupta M, Rossong H, Boone L, Manoranjan B, Ahmed S, Stukalin I, Lama S, Sutherland GR.
Healthcare spending versus mortality in central nervous system cancer: Has anything changed?
Neurooncol Pract. 2024 Apr 27;11(5):566-574. doi: 10.1093/nop/npae039. PMID: 39279779. Observational study˰ ˍ




Keul J, Sperling S, Rohde V, Mielke D, Ninkovic M.
Riluzole Reverses a Number of Undesirable Effects of Dexamethasone in Glioblastoma Cells.
Anticancer Res. 2024 Apr 27;44(5):1829-1835. doi: 10.21873/anticanres.16984. PMID: 38677733. Laboratory investigation. ˍ




Tropeano MP, Raspagliesi L, Bono BC, Baram A, Rossini Z, Franzini A, Navarria P, Clerici E, Bellu L, Simonelli M, Scorsetti M, Riva M, Politi LS, Pessina F.
Supramaximal resection: retrospective study on IDH-wildtype Glioblastomas based on the new RANO-Resect classification.
Acta Neurochir (Wien). 2024 Apr 27;166(1):196. doi: 10.1007/s00701-024-06090-2. PMID: 38676720. Observational study˰ ˍ




Wang F, Zhu Y, Wanggou S, Lin D, Su J, Li X, Tao E.
A natural compound melatonin enhances the effects of Nimotuzumab via inhibiting EGFR in glioblastoma.
Cancer Lett. 2024 Apr 27:216920. doi: 10.1016/j.canlet.2024.216920. PMID: 38679408. Laboratory investigation. ˍ




Zelt S, Cooney T, Yu S, Daral S, Krebs B, Markan R, Manley P, Kieran M, Govinda Raju S.
Disease burden and healthcare utilization in pediatric low-grade glioma: A United States retrospective study of linked claims and electronic health records.
Neurooncol Pract. 2024 Apr 27;11(5):583-592. doi: 10.1093/nop/npae037. PMID: 39279771. Observational study. ˍ




Sokol Z, Parsells P, Madineni R.
Liponeurocytoma: Rare Neoplasm of the Central Nervous System.
Cureus. 2024 Apr 28;16(4):e59221. doi: 10.7759/cureus.59221. PMID: 38807804. Case report. ˍ




Bashour G, Ismaiel N, Ebrahim Y, Ibrahim M, Deeb T, Khatab K, Ali MS, Alshehabi Z.
Primary spinal oligodendroglioma with intracranial extension: a case report.
Ann Med Surg (Lond). 2024 Apr 29;86(6):3757-3761. doi: 10.1097/MS9.0000000000002099. PMID: 38846823. Case report. ˍ




Gerritsen JKW, Young JS, Chang SM, Krieg SM, Jungk C, van den Bent MJ, Satoer DD, Ille S, Schucht P, Nahed BV, Broekman MLD, Berger M, De Vleeschouwer S, Vincent AJPE.
SUPRAMAX-study: supramaximal resection versus maximal resection for glioblastoma patients: study protocol for an international multicentre prospective cohort study (ENCRAM 2201).
BMJ Open. 2024 Apr 29;14(4):e082274. doi: 10.1136/bmjopen-2023-082274. PMID: 38684246. Interventional study protocol. ˍ




Gongala S, Garcia JA, Korakavi N, Patil N, Akbari H, Sloan A, Barnholtz-Sloan JS, Sun J, Griffith B, Poisson LM, Booth TC, Jain R, Mohan S, Nasralla MP, Bakas S, Tippareddy C, Puig J, Palmer JD, Shi W, Colen RR, Sotiras A, Ahn SS, Park YW, Davatzikos C, Badve C.
Sex-specific Differences in IDH1-Wildtype Glioblastoma patients in the ReSPOND Consortium.
AJNR Am J Neuroradiol. 2024 Apr 29:ajnr.A8319. doi: 10.3174/ajnr.A8319. PMID: 38684319. Observational study˰ ˍ




*Huang M, Liu Y, Peng J, Cheng Y.
Causal effects of immune cells in glioblastoma: a Bayesian Mendelian Randomization study.
Front Neurol. 2024 Apr 29;15:1375723. doi: 10.3389/fneur.2024.1375723. PMID: 38742049. Laboratory investigation. ˍ




Jung K, Kempter J, Prokop G, Herrmann T, Griessmair M, Kim SH, Delbridge C, Meyer B, Bernhardt D, Combs SE, Zimmer C, Wiestler B, Schmidt-Graf F, Metz MC.
Quantitative Assessment of Tumor Contact with Neurogenic Zones and Its Effects on Survival: Insights beyond Traditional Predictors.
Cancers (Basel). 2024 Apr 29;16(9):1743. doi: 10.3390/cancers16091743. PMID: 38730694. Observational study. ˍ




*Pichol-Thievend C, Anezo O, Pettiwala AM, Bourmeau G, Montagne R, Lyne AM, Guichet PO, Deshors P, Ballestín A, Blanchard B, Reveilles J, Ravi VM, Joseph K, Heiland DH, Julien B, Leboucher S, Besse L, Legoix P, Dingli F, Liva S, Loew D, Giani E, Ribecco V, Furumaya C, Marcos-Kovandzic L, Masliantsev K, Daubon T, Wang L, Diaz AA, Schnell O, Beck J, Servant N, Karayan-Tapon L, Cavalli FMG, Seano G.
VC-resist glioblastoma cell state: vessel co-option as a key driver of chemoradiation resistance.
Nat Commun. 2024 Apr 29;15(1):3602. doi: 10.1038/s41467-024-47985-z. PMID: 38684700. Laboratory investigation. ˍ




*Wang J, Hao Z, Li R, Wu W, Huang N, Zhang K, Hao S, Feng J, Chu J, Ji N.
Association of body mass index with clinical outcome of primary WHO grade 4 glioma.
Front Oncol. 2024 Apr 29;14:1318785. doi: 10.3389/fonc.2024.1318785. PMID: 38741777. Observational study. ˍ




Dono A, Zhu P, Takayasu T, Arevalo O, Riascos R, Tandon N, Ballester LY, Esquenazi Y.
Extent of Resection Thresholds in Molecular Subgroups of Newly Diagnosed Isocitrate Dehydrogenase-Wildtype Glioblastoma.
Neurosurgery. 2024 Apr 30. doi: 10.1227/neu.0000000000002964. PMID: 38687046. Observational study˰ ˍ




Ishaq HM, Yasin R, Mohammad IS, Fan Y, Li H, Shahzad M, Xu J.
The gut-brain-axis: A positive relationship between gut microbial dysbiosis and glioblastoma brain tumour.
Heliyon. 2024 Apr 30;10(9):e30494. doi: 10.1016/j.heliyon.2024.e30494. PMID: 38756585. Laboratory investigation. ˍ




Ngai CH, Teo C, Foo JY, Lim S, Koh JQS, Chan HM, Loh NW, Teo K.
Application of a Standardized Treatment Paradigm as a Strategy to Achieve Optimal Onco-Functional Balance in Glioma Surgery.
Brain Tumor Res Treat. 2024 Apr 30;12(2):100-108. doi: 10.14791/btrt.2024.0011. PMID: 38742258. Observational study. ˍ




O'Halloran K, Margol A, Davidson TB, Estrine D, Tamrazi B, Cotter JA, Ji J, Biegel JA.
Disease Evolution Monitored by Serial Cerebrospinal Fluid Liquid Biopsies in Two Cases of Recurrent Medulloblastoma.
Int J Mol Sci. 2024 Apr 30;25(9):4882. doi: 10.3390/ijms25094882. PMID: 38732099. Case report. ˍ




Rivas SR, Mendez Valdez MJ, Chandar JS, Desgraves JF, Lu VM, Ampie L, Singh EB, Seetharam D, Ramsoomair CK, Hudson A, Ingle SM, Govindarajan V, Doucet-O'Hare TT, DeMarino C, Heiss JD, Nath A, Shah AH.
Antiretroviral Drug Repositioning for Glioblastoma.
Cancers (Basel). 2024 Apr 30;16(9):1754. doi: 10.3390/cancers16091754. PMID: 38730705. Laboratory investigation. ˍ




Sarmiento JVM, Casis RM, Opinaldo PVA.
Understanding the Brain-Heart Connection Through a Case of Angry Glioma Syndrome.
Brain Tumor Res Treat. 2024 Apr 30;12(2):121-124. doi: 10.14791/btrt.2024.0004. PMID: 38742261. Case report. ˍ




Sato M, Han Q, Mizuta K, Mori R, Kang BM, Morinaga S, Kobayashi N, Ichikawa Y, Nakajima A, Hoffman RM.
Extensive Shrinkage and Long-term Stable Disease in a Teenage Female Patient With High-grade Glioma Treated With Temozolomide and Radiation in Combination With Oral Recombinant Methioninase and a Low-methionine Diet.
In Vivo. 2024 Apr 30;38(3):1459-1464. doi: 10.21873/invivo.13591. PMID: 38688589. Case report. ˍ











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