The most-cited Articles on
Glioblastoma

Akmal M, et al., Glioblastome Multiforme: A Bibliometric Analysis. World Neurosurg 2020

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Akmal M, Hasnain N, Rehan A, Iqbal U, Hashmi S, Fatima K, Farooq MZ, Khosa F, Siddiqi J, Khan MK.
Glioblastome Multiforme: A Bibliometric Analysis.
World Neurosurg. 2020 Apr;136:270-282→. doi: 10.1016/j.wneu.2020.01.027→. Epub 2020 Jan 14.PMID: 31953095→. Bibliometric analysis. ˍ

Classification

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Epidemiology, Risk factors

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Ohgaki H, Kleihues P.
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Etiology, Pathogenesis, Pathology

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Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor.
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Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.
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The somatic genomic landscape of glioblastoma.
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Chan JA, Krichevsky AM, Kosik KS.
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Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
Cancer Cell. 2012 Oct 16;22(4):425-37→. doi: 10.1016/j.ccr.2012.08.024→. PMID: 23079654→. Laboratory investigation. ˍ

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Turcan S, Rohle D, Goenka A, Walsh LA, Fang F, Yilmaz E, Campos C, Fabius AW, Lu C, Ward PS, Thompson CB, Kaufman A, Guryanova O, Levine R, Heguy A, Viale A, Morris LG, Huse JT, Mellinghoff IK, Chan TA.
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.
Nature. 2012 Feb 15;483(7390):479-83→. doi: 10.1038/nature10866→. PMID: 22343889→. Laboratory investigation. ˍ

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Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, Alexe G, Lawrence M, O'Kelly M, Tamayo P, Weir BA, Gabriel S, Winckler W, Gupta S, Jakkula L, Feiler HS, Hodgson JG, James CD, Sarkaria JN, Brennan C, Kahn A, Spellman PT, Wilson RK, Speed TP, Gray JW, Meyerson M, Getz G, Perou CM, Hayes DN; Cancer Genome Atlas Research Network.
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.
Cancer Cell. 2010 Jan 19;17(1):98-110→. doi: 10.1016/j.ccr.2009.12.020→. PMID: 20129251→. Laboratory investigation. ˍ

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Visvader JE, Lindeman GJ.
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.
Nat Rev Cancer. 2008 Sep 11;8(10):755-68→. doi: 10.1038/nrc2499→. PMID: 18784658→. Review. ˍ

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Wang R, Chadalavada K, Wilshire J, Kowalik U, Hovinga KE, Geber A, Fligelman B, Leversha M, Brennan C, Tabar V.
Glioblastoma stem-like cells give rise to tumour endothelium.
Nature. 2010 Nov 21;468(7325):829-33→. doi: 10.1038/nature09624→. PMID: 21102433→. Laboratory investigation. ˍ

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Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J, Qu C, Ding L, Huether R, Parker M, Zhang J, Gajjar A, Dyer MA, Mullighan CG, Gilbertson RJ, Mardis ER, Wilson RK, Downing JR, Ellison DW, Zhang J, Baker SJ; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project.
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.
Nat Genet. 2012 Jan 29;44(3):251-3→. doi: 10.1038/ng.1102→. PMID: 22286216→. Laboratory investigation. ˍ

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Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD.
IDH1 and IDH2 mutations in gliomas.
N Engl J Med. 2009 Feb 19;360(8):765-73→. doi: 10.1056/NEJMoa0808710→. PMID: 19228619→. Laboratory investigation. ˍ

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Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan KL, Xiong Y.
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.
Science. 2009 Apr 10;324(5924):261-5→. doi: 10.1126/science.1170944→. PMID: 19359588→. Laboratory investigation. ˍ

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Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ.
Loss of PTEN facilitates HIF-1-mediated gene expression.
Genes Dev. 2000 Feb 15;14(4):391-6→. doi: 10.1101/gad.14.4.391? PMID: 10691731→. Laboratory investigation. ˍ

Overall management

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Hochberg FH, Pruitt A.
Assumptions in the radiotherapy of glioblastoma.
Neurology. 1980 Sep 1;30(9):907-11→. doi: 10.1212/wnl.30.9.907→. PMID: 6252514→. Retrospective analysis. ˍ

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Omuro A, DeAngelis LM.
Glioblastoma and other malignant gliomas: a clinical review.
JAMA. 2013 Nov 6;310(17):1842-50→. doi: 10.1001/jama.2013.280319→. PMID: 24193082→. Review ˍ

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Wen PY, Kesari S.
Malignant gliomas in adults.
N Engl J Med. 2008 Jul 31;359(5):492-507→. doi: 10.1056/NEJMra0708126→. PMID: 18669428→. Review. ˍ
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Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, Degroot J, Wick W, Gilbert MR, Lassman AB, Tsien C, Mikkelsen T, Wong ET, Chamberlain MC, Stupp R, Lamborn KR, Vogelbaum MA, van den Bent MJ, Chang SM.
Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group.
J Clin Oncol. 2010 Mar 15;28(11):1963-72→. doi: 10.1200/JCO.2009.26.3541→. PMID: 20231676→. Guidelines. ˍ

Treatment

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Barth RF, Coderre JA, Vicente MG, Blue TE.
Boron neutron capture therapy of cancer: current status and future prospects.
Clin Cancer Res. 2005 Jun 1;11(11):3987-4002→. doi: 10.1158/1078-0432.CCR-05-0035→. PMID: 15930333→. Review. ˍ

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Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK.
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.
Cancer Cell. 2007 Jan 15;11(1):83-95→. doi: 10.1016/j.ccr.2006.11.021 ˍ. PMID: 17222792→. Phase 2 trial. ˍ

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Brandsma D, Stalpers L, Taal W, Sminia P, van den Bent MJ.
Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas.
Lancet Oncol. 2008 May 1;9(5):453-61→. doi: 10.1016/S1470-2045(08)70125-6→. PMID: 18452856→. Review. ˍ

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Brem H, Piantadosi S, Burger PC, Walker M, Selker R, Vick NA, Black K, Sisti M, Brem S, Mohr G, Muller P, Morawetz R, Schold SC.
Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group.
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Chinot OL, Wick W, Mason W, Henriksson R, Saran F, Nishikawa R, Carpentier AF, Hoang-Xuan K, Kavan P, Cernea D, Brandes AA, Hilton M, Abrey L, Cloughesy T.
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma.
N Engl J Med. 2014 Feb 20;370(8):709-22→. doi: 10.1056/NEJMoa1308345→. PMID: 24552318→. Phase 3 trial. ˍ

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Curran WJ Jr, Scott CB, Horton J, Nelson JS, Weinstein AS, Fischbach AJ, Chang CH, Rotman M, Asbell SO, Krisch RE, et al.
Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials.
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Fine HA, Dear KB, Loeffler JS, Black PM, Canellos GP.
Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults.
Cancer. 1993 Apr 15;71(8):2585-97→. doi: 10.1002/1097-0142(19930415)71:8<2585::aid-cncr2820710825>3.0.co;2-s→. PMID: 8453582→. Meta-analysis. ˍ

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Friedman HS, Prados MD, Wen PY, Mikkelsen T, Schiff D, Abrey LE, Yung WK, Paleologos N, Nicholas MK, Jensen R, Vredenburgh J, Huang J, Zheng M, Cloughesy T.
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma.
J Clin Oncol. 2009 Aug 31;27(28):4733-40→. doi: 10.1200/JCO.2008.19.8721→. PMID: 19720927→. Phase 2 trial. ˍ

◽

Gilbert MR, Dignam JJ, Armstrong TS, Wefel JS, Blumenthal DT, Vogelbaum MA, Colman H, Chakravarti A, Pugh S, Won M, Jeraj R, Brown PD, Jaeckle KA, Schiff D, Stieber VW, Brachman DG, Werner-Wasik M, Tremont-Lukats IW, Sulman EP, Aldape KD, Curran WJ Jr, Mehta MP.
A randomized trial of bevacizumab for newly diagnosed glioblastoma.
N Engl J Med. 2014 Feb 20;370(8):699-708→. doi: 10.1056/NEJMoa1308573→. PMID: 24552317→. Randomized trial. ˍ

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Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, Bromberg JE, Hau P, Mirimanoff RO, Cairncross JG, Janzer RC, Stupp R.
MGMT gene silencing and benefit from temozolomide in glioblastoma.
N Engl J Med. 2005 Mar 10;352(10):997-1003→. doi: 10.1056/NEJMoa043331→. PMID: 15758010→. Clinical trial. ˍ

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Kreisl TN, Kim L, Moore K, Duic P, Royce C, Stroud I, Garren N, Mackey M, Butman JA, Camphausen K, Park J, Albert PS, Fine HA.
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma.
J Clin Oncol. 2008 Dec 29. 2009;27(5):740-5→. doi: 10.1200/JCO.2008.16.3055→. PMID: 19114704→. Phase 2 trial. ˍ

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Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, Hess K, Michael C, Miller D, Sawaya R.
A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival.
J Neurosurg. 2001 Aug;95(2):190-8→. doi: 10.3171/jns.2001.95.2.0190→. PMID: 11780887→. Retrospective analysis. ˍ

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Markert JM, Medlock MD, Rabkin SD, Gillespie GY, Todo T, Hunter WD, Palmer CA, Feigenbaum F, Tornatore C, Tufaro F, Martuza RL.
Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial
Gene Ther. 2000 May 25;7(10):867-74→. doi: 10.1038/sj.gt.3301205→. PMID: 10845725→. Phase 1 trial. ˍ

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Mellinghoff IK, Wang MY, Vivanco I, Haas-Kogan DA, Zhu S, Dia EQ, Lu KV, Yoshimoto K, Huang JH, Chute DJ, Riggs BL, Horvath S, Liau LM, Cavenee WK, Rao PN, Beroukhim R, Peck TC, Lee JC, Sellers WR, Stokoe D, Prados M, Cloughesy TF, Sawyers CL, Mischel PS.
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
N Engl J Med. 2005 Nov 10;353(19):2012-24→. doi: 10.1056/NEJMoa051918→. PMID: 16282176→. Clinical study. ˍ
Erratum in: N Engl J Med. 2006 Feb 23;354(8):884→. doi: 10.1056/NEJMx060009→. Correction. ˍ

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Millauer B, Shawver LK, Plate KH, Risau W, Ullrich A.
Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant.
Nature. 1994 Feb 10;367(6463):576-9→. doi: 10.1038/367576a0→. PMID: 8107827→. Laboratory investigation. ˍ

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Norden AD, Young GS, Setayesh K, Muzikansky A, Klufas R, Ross GL, Ciampa AS, Ebbeling LG, Levy B, Drappatz J, Kesari S, Wen PY.
Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence.
Neurology. 2008 Mar 4;70(10):779-87→. doi: 10.1212/01.wnl.0000304121.57857.38→. PMID: 18316689→. Retrospective analysis. ˍ

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Ohgaki H, Dessen P, Jourde B, Horstmann S, Nishikawa T, Di Patre PL, Burkhard C, Schüler D, Probst-Hensch NM, Maiorka PC, Baeza N, Pisani P, Yonekawa Y, Yasargil MG, Lütolf UM, Kleihues P.
Genetic pathways to glioblastoma: a population-based study.
Cancer Res. 2004 Oct 1;64(19):6892-9→. doi: 10.1158/0008-5472.CAN-04-1337→. PMID: 15466178→. Retrospective analysis. ˍ

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Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ; ALA-Glioma Study Group.
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Lancet Oncol. 2006 Apr 13;7(5):392-401→. doi: 10.1016/S1470-2045(06)70665-9→. PMID: 16648043→. Phase 3 trial. ˍ

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Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross JG, Mirimanoff RO; European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups; National Cancer Institute of Canada Clinical Trials Group.
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial.
Lancet Oncol. 2009 Mar 9. 2009;10(5):459-66→. doi: 10.1016/S1470-2045(09)70025-7→. PMID: 19269895→. Phase 3 trial. ˍ

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Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group.
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.
N Engl J Med. 2005 Mar 10;352(10):987-96→. doi: 10.1056/NEJMoa043330→. PMID: 15758009→. Phase 3 trial. ˍ

◽

Stupp R, Dietrich PY, Ostermann Kraljevic S, Pica A, Maillard I, Maeder P, Meuli R, Janzer R, Pizzolato G, Miralbell R, Porchet F, Regli L, de Tribolet N, Mirimanoff RO, Leyvraz S.
Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide.
J Clin Oncol. 2002 Mar 1;20(5):1375-82→. doi: 10.1200/JCO.2002.20.5.1375→. PMID: 11870182→. Phase 2 trial. ˍ

◽

Sugahara T, Korogi Y, Kochi M, Ikushima I, Shigematu Y, Hirai T, Okuda T, Liang L, Ge Y, Komohara Y, Ushio Y, Takahashi M.
Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas.
J Magn Reson Imaging. 1999 Jan;9(1):53-60→. doi: 10.1002/(sici)1522-2586(199901)9:1<53::aid-jmri7>3.0.co;2-2→. PMID: 10030650→. Prospective study. ˍ

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Van Meir EG, Hadjipanayis CG, Norden AD, Shu HK, Wen PY, Olson JJ.
Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma.
CA Cancer J Clin. 2010 May 5;60(3):166-93→. doi: 10.3322/caac.20069→. PMID: 20445000→. Review. ˍ

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Vredenburgh JJ, Desjardins A, Herndon JE 2nd, Marcello J, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Sampson J, Wagner M, Bailey L, Bigner DD, Friedman AH, Friedman HS.
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme.
J Clin Oncol. 2007 Oct 20;25(30):4722-9→. doi: 10.1200/JCO.2007.12.2440→. PMID: 17947719→. Phase 2 trial. ˍ

◽

Vredenburgh JJ, Desjardins A, Herndon JE 2nd, Dowell JM, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Wagner M, Bigner DD, Friedman AH, Friedman HS.
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma.
Clin Cancer Res. 2007 Feb 15;13(4):1253-9→. doi: 10.1158/1078-0432.CCR-06-2309→. PMID: 17317837→. Phase 2 trial. ˍ

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Walker MD, Green SB, Byar DP, Alexander E Jr, Batzdorf U, Brooks WH, Hunt WE, MacCarty CS, Mahaley MS Jr, Mealey J Jr, Owens G, Ransohoff J 2nd, Robertson JT, Shapiro WR, Smith KR Jr, Wilson CB, Strike TA.
Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery.
N Engl J Med. 1980 Dec 4;303(23):1323-9→. doi: 10.1056/NEJM198012043032303→. PMID: 7001230→. Prospective study. ˍ

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Walker MD, Alexander E Jr, Hunt WE, MacCarty CS, Mahaley MS Jr, Mealey J Jr, Norrell HA, Owens G, Ransohoff J, Wilson CB, Gehan EA, Strike TA.
Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial.
J Neurosurg. 1978 Sep;49(3):333-43→. doi: 10.3171/jns.1978.49.3.0333→. PMID: 355604→. Prospective study. ˍ

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Westphal M, Hilt DC, Bortey E, Delavault P, Olivares R, Warnke PC, Whittle IR, Jääskeläinen J, Ram Z.
A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma.
Neuro Oncol. 2003 Apr 1;5(2):79-88→. doi: 10.1093/neuonc/5.2.79→. PMID: 12672279→. Phase 3 trial. ˍ

◽

Wong ET, Hess KR, Gleason MJ, Jaeckle KA, Kyritsis AP, Prados MD, Levin VA, Yung WK.
Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials.
J Clin Oncol. 1999 Aug 1;17(8):2572-8→. doi: 10.1200/JCO.1999.17.8.2572→. PMID: 10561324→. Phase 2 trial. ˍ

◽

Yung WK, Albright RE, Olson J, Fredericks R, Fink K, Prados MD, Brada M, Spence A, Hohl RJ, Shapiro W, Glantz M, Greenberg H, Selker RG, Vick NA, Rampling R, Friedman H, Phillips P, Bruner J, Yue N, Osoba D, Zaknoen S, Levin VA.
A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse.
Br J Cancer. 2000 Aug 8;83(5):588-93→. doi: 10.1054/bjoc.2000.1316→. PMID: 10944597→. Phase 2 trial. ˍ