|
|
|
|
◽◽◽
|
Hachem LD, Mansouri A, Juraschka K,
Taslimi S, Pirouzmand F, Zadeh G.
Citation
classics in neuro-oncology: assessment of historical trends and
scientific progress.
Neuro
Oncol. 2017 May 20;19(9):1158-1172→.
doi: 10.1093/neuonc/nox053→.
PMID: 28531344→.
Bibliometric
analysis. ˍ
|
|
|
Classification
|
|
◽
|
Daumas-Duport C, Scheithauer B,
O'Fallon J, Kelly P.
Grading
of astrocytomas. A simple and reproducible method.
Cancer.
1988 Nov 15;62(10):2152-65→.
doi:
10.1002/1097-0142(19881115)62:10<2152::aid-cncr2820621015>3.0.co;2-t→.
PMID: 3179928→.
Observational study. ˍ
|
|
|
◽
|
Kleihues P, Louis DN, Scheithauer
BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK.
The
WHO classification of tumors of the nervous system.
J
Neuropathol Exp Neurol. 2002 Mar 1;61(3):215-25→.
doi: 10.1093/jnen/61.3.215→.
PMID: 11895036→.
Review. ˍ
|
|
|
◽
|
Kleihues P, Burger PC, Scheithauer
BW.
The
new WHO classification of brain tumours.
Brain
Pathol. 1993 Jul;3(3):255-68→.
doi: 10.1111/j.1750-3639.1993.tb00752.x→.
PMID: 8293185→.
Review. ˍ
|
|
|
◽
|
Louis DN, Ohgaki H, Wiestler OD,
Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P.
The
2007 WHO classification of tumours of the central nervous
system.
Acta
Neuropathol. 2007 Jul 6;114(2):97-109→.
doi: 10.1007/s00401-007-0243-4→.
PMID: 17618441→.
Review. ˍ
Erratum
in: Acta Neuropathol.
2007 Sep 28;114(5):547→.
doi: 10.1007/s00401-007-0278-6→.
Correction. ˍ
|
|
|
◽
|
Phillips HS, Kharbanda S, Chen R,
Forrest WF, Soriano RH, Wu TD, Misra A, Nigro JM, Colman H,
Soroceanu L, Williams PM, Modrusan Z, Feuerstein BG, Aldape K.
Molecular
subclasses of high-grade glioma predict prognosis, delineate a
pattern of disease progression, and resemble stages in
neurogenesis.
Cancer
Cell. 2006 Mar 1;9(3):157-73→.
doi: 10.1016/j.ccr.2006.02.019→.
PMID: 16530701→.
Laboratory investigation. ˍ
|
|
|
◽
|
Pomeroy SL, Tamayo P, Gaasenbeek M,
Sturla LM, Angelo M, McLaughlin ME, Kim JY, Goumnerova LC, Black
PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C,
Biegel JA, Poggio T, Mukherjee S, Rifkin R, Califano A,
Stolovitzky G, Louis DN, Mesirov JP, Lander ES, Golub TR.
Prediction
of central nervous system embryonal tumour outcome based on gene
expression.
Nature.
2002 Jan 24;415(6870):436-42→.
doi: 10.1038/415436a→.
PMID: 11807556→.
Laboratory investigation. ˍ
|
|
|
Etiology,
Pathogenesis, Pathology
|
|
◽
|
Aboody KS, Brown A, Rainov NG,
Bower KA, Liu S, Yang W, Small JE, Herrlinger U, Ourednik V, Black
PM, Breakefield XO, Snyder EY.
Neural
stem cells display extensive tropism for pathology in adult brain:
evidence from intracranial gliomas.
Proc
Natl Acad Sci USA. 2000 Nov 7;97(23):12846-51→.
doi: 10.1073/pnas.97.23.12846→.
PMID: 11070094→.
Laboratory investigation. ˍ
Erratum
in: Proc
Natl Acad Sci USA. 2001 Jan 16;98(2):777→.
doi: 10.1073/pnas.98.2.777-d→.
Correction. ˍ
|
|
|
◽
|
Bao S, Wu Q, McLendon RE, Hao Y,
Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN.
Glioma
stem cells promote radioresistance by preferential activation of
the DNA damage response.
Nature.
2006 Oct 18. 2006;444(7120):756-60→.
doi: 10.1038/nature05236→.
PMID: 17051156→.
Laboratory investigation. ˍ
|
|
|
◽
|
Bao S, Wu Q, Sathornsumetee S, Hao
Y, Li Z, Hjelmeland AB, Shi Q, McLendon RE, Bigner DD, Rich JN.
Stem
cell-like glioma cells promote tumor angiogenesis through vascular
endothelial growth factor.
Cancer
Res. 2006 Aug 15;66(16):7843-8→.
doi: 10.1158/0008-5472.CAN-06-1010→.
PMID: 16912155→.
Laboratory investigation. ˍ
|
|
|
◽
|
Beier D, Hau P, Proescholdt M,
Lohmeier A, Wischhusen J, Oefner PJ, Aigner L, Brawanski A,
Bogdahn U, Beier CP.
CD133(+)
and CD133(-) glioblastoma-derived cancer stem cells show
differential growth characteristics and molecular profiles.
Cancer
Res. 2007 May 1;67(9):4010-5→.
doi: 10.1158/0008-5472.CAN-06-4180→.
PMID: 17483311→.
Laboratory investigation. ˍ
|
|
|
◽
|
Berman DM, Karhadkar SS, Hallahan
AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK,
Taipale J, Olson JM, Beachy PA.
Medulloblastoma
growth inhibition by hedgehog pathway blockade.
Science.
2002 Aug 30;297(5586):1559-61→.
doi: 10.1126/science.1073733→.
PMID: 12202832→.
Laboratory investigation. ˍ
|
|
|
◽
|
Bos PD, Zhang XH, Nadal C, Shu W,
Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens
JA, Massagué J.
Genes
that mediate breast cancer metastasis to the brain.
Nature.
2009 May 6;459(7249):1005-9→.
doi: 10.1038/nature08021→.
PMID: 19421193→.
Laboratory investigation. ˍ
|
|
|
◽
|
Calabrese C, Poppleton H, Kocak M,
Hogg TL, Fuller C, Hamner B, Oh EY, Gaber MW, Finklestein D, Allen
M, Frank A, Bayazitov IT, Zakharenko SS, Gajjar A, Davidoff A,
Gilbertson RJ.
A
perivascular niche for brain tumor stem cells.
Cancer
Cell. 2007 Jan 1;11(1):69-82→.
doi: 10.1016/j.ccr.2006.11.020→.
PMID: 17222791→.
Laboratory investigation. ˍ
|
|
|
◽
|
Chan JA, Krichevsky AM, Kosik KS.
MicroRNA-21
is an antiapoptotic factor in human glioblastoma cells.
Cancer
Res. 2005 Jul 15;65(14):6029-33→.
doi: 10.1158/0008-5472.CAN-05-0137→.
PMID: 16024602→.
Laboratory investigation. ˍ
|
|
|
◽
|
Ciafrè SA, Galardi S,
Mangiola A, Ferracin M, Liu CG, Sabatino G, Negrini M, Maira G,
Croce CM, Farace MG.
Extensive
modulation of a set of microRNAs in primary glioblastoma.
Biochem
Biophys Res Commun. 2005 Jul 18;334(4):1351-8→.
doi: 10.1016/j.bbrc.2005.07.030→.
PMID: 16039986→.
Laboratory investigation. ˍ
|
|
|
◽
|
Clement V, Sanchez P, de Tribolet
N, Radovanovic I, Ruiz i Altaba A.
HEDGEHOG-GLI1
signaling regulates human glioma growth, cancer stem cell
self-renewal, and tumorigenicity.
Curr
Biol. 2006 Dec 28. 2007;17(2):165-72→.
doi: 10.1016/j.cub.2006.11.033→.
PMID: 17196391→.
Laboratory investigation. ˍ
Erratum
in: Curr Biol. 2007 Jan 22;17(2):192→.
doi: 10.1016/j.cub.2007.01.024→.
Correction.
ˍ
|
|
|
◽
|
Dang L, White DW, Gross S, Bennett
BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan
MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD,
Cantley LC, Thompson CB, Vander Heiden MG, Su SM.
Cancer-associated
IDH1 mutations produce 2-hydroxyglutarate.
Nature.
2009 Nov 22;462(7274):739-44→.
doi: 10.1038/nature08617→.
PMID: 19935646→.
Laboratory investigation. ˍ
Addendum
in: Nature. 2010 Jun 17;465(7300):966→.
doi: 10.1038/nature09132→.
PMID: 20559394→.
Addendum. ˍ
|
|
|
◽
|
Fulda S, Wick W, Weller M, Debatin
KM.
Smac
agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced
apoptosis and induce regression of malignant glioma in vivo.
Nat
Med. 2002 Jul 15;8(8):808-15→.
doi: 10.1038/nm735→.
PMID: 12118245→.
Laboratory investigation. ˍ
|
|
|
◽
|
Furnari FB, Fenton T, Bachoo RM,
Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN,
Brennan C, Chin L, DePinho RA, Cavenee WK.
Malignant
astrocytic glioma: genetics, biology, and paths to
treatment.
Genes
Dev. 2007 Nov 1;21(21):2683-710→.
doi: 10.1101/gad.1596707→.
PMID: 17974913→.
Review. ˍ
|
|
|
◽
|
Galli R, Binda E, Orfanelli U,
Cipelletti B, Gritti A, De Vitis S, Fiocco R, Foroni C, Dimeco F,
Vescovi A.
Isolation
and characterization of tumorigenic, stem-like neural precursors
from human glioblastoma.
Cancer
Res. 2004 Oct 1;64(19):7011-21→.
doi: 10.1158/0008-5472.CAN-04-1364→.
PMID: 15466194→.
Laboratory investigation. ˍ
|
|
|
◽
|
Giese A, Bjerkvig R, Berens ME,
Westphal M.
Cost
of migration: invasion of malignant gliomas and implications for
treatment.
J
Clin Oncol. 2003 Apr 15;21(8):1624-36→.
doi: 10.1200/JCO.2003.05.063→.
PMID: 12697889→.
Review. ˍ
|
|
|
◽
|
Hemmati HD, Nakano I, Lazareff JA,
Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI.
Cancerous
stem cells can arise from pediatric brain tumors.
Proc
Natl Acad Sci USA. 2003 Nov 26;100(25):15178-83→.
doi: 10.1073/pnas.2036535100→.
PMID: 14645703→.
Laboratory investigation. ˍ
|
|
|
◽
|
Kanzawa T, Germano IM, Komata T,
Ito H, Kondo Y, Kondo S.
Role
of autophagy in temozolomide-induced cytotoxicity for malignant
glioma cells.
Cell
Death Differ. 2004 Jan 9;11(4):448-57→.
doi: 10.1038/sj.cdd.4401359→.
PMID: 14713959→.
Laboratory investigation. ˍ
|
|
|
◽
|
Kondo T, Setoguchi T, Taga T.
Persistence
of a small subpopulation of cancer stem-like cells in the C6
glioma cell line.
Proc
Natl Acad Sci USA. 2004 Jan 7;101(3):781-6→.
doi: 10.1073/pnas.0307618100→.
PMID: 14711994→.
Laboratory investigation. ˍ
|
|
|
◽
|
Lee J, Kotliarova S, Kotliarov Y,
Li A, Su Q, Donin NM, Pastorino S, Purow BW, Christopher N, Zhang
W, Park JK, Fine HA.
Tumor
stem cells derived from glioblastomas cultured in bFGF and EGF
more closely mirror the phenotype and genotype of primary tumors
than do serum-cultured cell lines.
Cancer
Cell. 2006 May 1;9(5):391-403→.
doi: 10.1016/j.ccr.2006.03.030→.
PMID: 16697959→.
Laboratory investigation. ˍ
|
|
|
◽
|
Libermann TA, Nusbaum HR, Razon N,
Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A,
Schlessinger J.
Amplification,
enhanced expression and possible rearrangement of EGF receptor
gene in primary human brain tumours of glial origin.
Nature.
1985 Jan 10;313(5998):144-7→.
doi: 10.1038/313144a0→.
PMID: 2981413→.
Laboratory investigation. ˍ
|
|
|
◽
|
Liu G, Yuan X, Zeng Z, Tunici P, Ng
H, Abdulkadir IR, Lu L, Irvin D, Black KL, Yu JS.
Analysis
of gene expression and chemoresistance of CD133+ cancer stem cells
in glioblastoma.
Mol
Cancer. 2006 Dec 2;5:67→.
doi: 10.1186/1476-4598-5-67→.
PMID: 17140455→.
Laboratory investigation. ˍ
|
|
|
◽
|
Lyden D, Young AZ, Zagzag D, Yan W,
Gerald W, O'Reilly R, Bader BL, Hynes RO, Zhuang Y, Manova K,
Benezra R.
Id1
and Id3 are required for neurogenesis, angiogenesis and
vascularization of tumour xenografts.
Nature.
1999 Oct 14;401(6754):670-7→.
doi: 10.1038/44334→.
PMID: 10537105→.
Laboratory investigation. ˍ
|
|
|
◽
|
Maher EA, Furnari FB, Bachoo RM,
Rowitch DH, Louis DN, Cavenee WK, DePinho RA.
Malignant
glioma: genetics and biology of a grave matter.
Genes
Dev. 2001 Jun 1;15(11):1311-33→.
doi: 10.1101/gad.891601→.
PMID: 11390353→.
Review. ˍ
|
|
|
◽
|
McLendon R, et al., Cancer Genome
Atlas Research Network.
Comprehensive
genomic characterization defines human glioblastoma genes and core
pathways.
Nature.
2008 Sep 4. 2008;455(7216):1061-8→.
doi: 10.1038/nature07385→.
PMID: 18772890→.
Laboratory investigation. ˍ
Erratum
in: Nature. 2013 Feb 6. 2013;494(7438):506→.
doi. 10.1038/nature11903→.
Correction. ˍ
|
|
|
◽
|
Mercer WE, Shields MT, Amin M,
Sauve GJ, Appella E, Romano JW, Ullrich SJ.
Negative
growth regulation in a glioblastoma tumor cell line that
conditionally expresses human wild-type p53.
Proc
Natl Acad Sci USA. 1990 Aug 1;87(16):6166-70→.
doi: 10.1073/pnas.87.16.6166→.
PMID: 2143581→.
Laboratory investigation. ˍ
|
|
|
◽
|
Nakamizo A, Marini F, Amano T, Khan
A, Studeny M, Gumin J, Chen J, Hentschel S, Vecil G, Dembinski J,
Andreeff M, Lang FF.
Human
bone marrow-derived mesenchymal stem cells in the treatment of
gliomas.
Cancer
Res. 2005 Apr 15;65(8):3307-18→.
doi: 10.1158/0008-5472.CAN-04-1874→.
PMID: 15833864→.
Laboratory investigation. ˍ
Erratum in: Cancer Res.
2006 Jun 1;66(11):5975→.
doi: 10.1158/0008-5472.CAN-66-11-COR1→.
Correction.
ˍ
|
|
|
◽
|
Nishikawa R, Ji XD, Harmon RC,
Lazar CS, Gill GN, Cavenee WK, Huang HJ.
A
mutant epidermal growth factor receptor common in human glioma
confers enhanced tumorigenicity.
Proc
Natl Acad Sci USA. 1994 Aug 2;91(16):7727-31→.
doi: 10.1073/pnas.91.16.7727→.
PMID: 8052651→.
Laboratory investigation. ˍ
|
|
|
◽
|
Noushmehr H, Weisenberger DJ,
Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE,
Sulman EP, Bhat KP, Verhaak RG, Hoadley KA, Hayes DN, Perou CM,
Schmidt HK, Ding L, Wilson RK, Van Den Berg D, Shen H, Bengtsson
H, Neuvial P, Cope LM, Buckley J, Herman JG, Baylin SB, Laird PW,
Aldape K; Cancer Genome Atlas Research Network.
Identification
of a CpG island methylator phenotype that defines a distinct
subgroup of glioma.
Cancer
Cell. 2010 Apr 15;17(5):510-22→.
doi: 10.1016/j.ccr.2010.03.017→.
PMID: 20399149→.
Laboratory investigation. ˍ
|
|
|
◽
|
Ohgaki H, Kleihues P.
Genetic
pathways to primary and secondary glioblastoma.
Am
J Pathol. 2007 May 1;170(5):1445-53→.
doi: 10.2353/ajpath.2007.070011→.
PMID: 17456751→.
Review. ˍ
|
|
|
◽
|
Parsons DW, Jones S, Zhang X, Lin
JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL,
Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y,
Busam DA, Tekleab H, Diaz LA Jr, Hartigan J, Smith DR, Strausberg
RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R,
Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler
KW.
An
integrated genomic analysis of human glioblastoma
multiforme.
Science.
2008 Sep 4;321(5897):1807-12→.
doi: 10.1126/science.1164382→.
PMID: 18772396→.
Laboratory investigation. ˍ
|
|
|
◽
|
Piccirillo SG, Reynolds BA, Zanetti
N, Lamorte G, Binda E, Broggi G, Brem H, Olivi A, Dimeco F,
Vescovi AL.
Bone
morphogenetic proteins inhibit the tumorigenic potential of human
brain tumour-initiating cells.
Nature.
2006 Dec 7;444(7120):761-5→.
doi: 10.1038/nature05349→.
PMID: 17151667→.
Laboratory investigation. ˍ
|
|
|
◽
|
Plate KH, Breier G, Weich HA, Risau
W.
Vascular
endothelial growth factor is a potential tumour angiogenesis
factor in human gliomas in vivo.
Nature.
1992 Oct 29;359(6398):845-8→.
doi: 10.1038/359845a0→.
PMID: 1279432→.
Laboratory investigation. ˍ
|
|
|
◽
|
Seoane J, Le HV, Shen L, Anderson
SA, Massagué J.
Integration
of Smad and forkhead pathways in the control of neuroepithelial
and glioblastoma cell proliferation.
Cell.
2004 Apr 16;117(2):211-23→.
doi: 10.1016/s0092-8674(04)00298-3→.
PMID: 15084259→.
Laboratory investigation. ˍ
|
|
|
◽
|
Shih C, Padhy LC, Murray M,
Weinberg RA.
Transforming
genes of carcinomas and neuroblastomas introduced into mouse
fibroblasts.
Nature.
1981 Mar 19;290(5803):261-4→.
doi: 10.1038/290261a0→.
PMID: 7207618→.
Laboratory investigation. ˍ
|
|
|
◽
|
Sidransky D, Mikkelsen T,
Schwechheimer K, Rosenblum ML, Cavanee W, Vogelstein B.
Clonal
expansion of p53 mutant cells is associated with brain tumour
progression.
Nature.
1992 Feb 27;355(6363):846-7→.
doi: 10.1038/355846a0→.
PMID: 1311419→.
Laboratory investigation. ˍ
|
|
|
◽
|
Singh SK, Hawkins C, Clarke ID,
Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB.
Identification
of human brain tumour initiating cells.
Nature.
2004 Nov 18;432(7015):396-401→.
doi: 10.1038/nature03128→.
PMID: 15549107→.
Laboratory investigation. ˍ
|
|
|
◽
|
Singh SK, Clarke ID, Terasaki M,
Bonn VE, Hawkins C, Squire J, Dirks PB.
Identification
of a cancer stem cell in human brain tumors.
Cancer
Res. 2003 Sep 15;63(18):5821-8→.
PMID: 14522905→.
Laboratory investigation. ˍ
|
|
|
◽
|
Skog J, Würdinger T, van Rijn
S, Meijer DH, Gainche L, Sena-Esteves M, Curry WT Jr, Carter BS,
Krichevsky AM, Breakefield XO.
Glioblastoma
microvesicles transport RNA and proteins that promote tumour
growth and provide diagnostic biomarkers.
Nat
Cell Biol. 2008 Nov 16;10(12):1470-6→.
doi: 10.1038/ncb1800→.
PMID: 19011622→.
Laboratory investigation. ˍ
|
|
|
◽
|
Verhaak RG, Hoadley KA, Purdom E,
Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov
JP, Alexe G, Lawrence M, O'Kelly M, Tamayo P, Weir BA, Gabriel S,
Winckler W, Gupta S, Jakkula L, Feiler HS, Hodgson JG, James CD,
Sarkaria JN, Brennan C, Kahn A, Spellman PT, Wilson RK, Speed TP,
Gray JW, Meyerson M, Getz G, Perou CM, Hayes DN; Cancer Genome
Atlas Research Network.
Integrated
genomic analysis identifies clinically relevant subtypes of
glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR,
and NF1.
Cancer
Cell. 2010 Jan 19;17(1):98-110→.
doi: 10.1016/j.ccr.2009.12.020→.
PMID: 20129251→.
Laboratory investigation. ˍ
|
|
|
◽
|
Winkler F, Kozin SV, Tong RT, Chae
SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di
Tomaso E, Munn LL, Jain RK.
Kinetics
of vascular normalization by VEGFR2 blockade governs brain tumor
response to radiation: role of oxygenation, angiopoietin-1, and
matrix metalloproteinases.
Cancer
Cell. 2004 Dec 1;6(6):553-63→.
doi: 10.1016/j.ccr.2004.10.011→.
PMID: 15607960→.
Laboratory investigation. ˍ
|
|
|
◽
|
Wong AJ, Ruppert JM, Bigner SH,
Grzeschik CH, Humphrey PA, Bigner DS, Vogelstein B.
Structural
alterations of the epidermal growth factor receptor gene in human
gliomas.
Proc
Natl Acad Sci USA. 1992 Apr 1;89(7):2965-9→.
doi: 10.1073/pnas.89.7.2965→.
PMID: 1557402→.
Laboratory investigation. ˍ
|
|
|
◽
|
Wong AJ, Bigner SH, Bigner DD,
Kinzler KW, Hamilton SR, Vogelstein B.
Increased
expression of the epidermal growth factor receptor gene in
malignant gliomas is invariably associated with gene
amplification.
Proc
Natl Acad Sci USA. 1987 Oct 1;84(19):6899-903→.
doi: 10.1073/pnas.84.19.6899→.
PMID: 3477813→.
Laboratory investigation. ˍ
|
|
|
◽
|
Yan H, Parsons DW, Jin G, McLendon
R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins
GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW,
Velculescu VE, Vogelstein B, Bigner DD.
IDH1
and IDH2 mutations in gliomas.
N
Engl J Med. 2009 Feb 19;360(8):765-73→.
doi: 10.1056/NEJMoa0808710→.
PMID: 19228619→.
Laboratory investigation. ˍ
|
|
|
Overall
management
|
|
◽
|
DeAngelis LM.
Brain
tumors.
N Engl J
Med. 2001 Jan 11;344(2):114-23→.
doi: 10.1056/NEJM200101113440207→.
PMID: 11150363→.
Review. ˍ
|
|
|
◽
|
Macdonald DR, Cascino TL, Schold SC
Jr, Cairncross JG.
Response
criteria for phase II studies of supratentorial malignant
glioma.
J Clin
Oncol. 1990 Jul;8(7):1277-80→.
doi: 10.1200/JCO.1990.8.7.1277→.
PMID: 2358840→.
Guidelines. ˍ
|
|
|
◽
|
Áfra
D.
Chemotherapy
in adult high-grade glioma: a systematic review and meta-analysis
of individual patient data from 12 randomised trials.
Lancet.
2002 Mar 23;359(9311):1011-8→.
doi: 10.1016/s0140-6736(02)08091-1→.
PMID: 11937180→.
Review. ˍ
|
|
|
◽
|
Wen PY, Macdonald DR, Reardon DA,
Cloughesy TF, Sorensen AG, Galanis E, Degroot J, Wick W, Gilbert
MR, Lassman AB, Tsien C, Mikkelsen T, Wong ET, Chamberlain MC,
Stupp R, Lamborn KR, Vogelbaum MA, van den Bent MJ, Chang
SM.
Updated
response assessment criteria for high-grade gliomas: response
assessment in neuro-oncology working group.
J
Clin Oncol. 2010 Mar 15;28(11):1963-72→.
doi: 10.1200/JCO.2009.26.3541→.
PMID: 20231676→.
Guidelines. ˍ
|
|
|
◽
|
Wen PY, Kesari S.
Malignant
gliomas in adults.
N
Engl J Med. 2008 Jul 31;359(5):492-507→.
doi: 10.1056/NEJMra0708126→.
PMID: 18669428→.
Review. ˍ
Erratum
in: N Engl J Med. 2008 Aug 21;359(8):877→.
doi: 10.1056/NEJMx080027→.
Correction. ˍ
|
|
|
◽
|
Young H, Baum R, Cremerius U,
Herholz K, Hoekstra O, Lammertsma AA, Pruim J, Price P.
Measurement
of clinical and subclinical tumour response using
[18F]-fluorodeoxyglucose and positron emission tomography: review
and 1999 EORTC recommendations. European Organization for Research
and Treatment of Cancer (EORTC) PET Study Group.
Eur
J Cancer. 1999 Dec 1;35(13):1773-82→.
doi: 10.1016/s0959-8049(99)00229-4→.
PMID: 10673991→.
Guidelines. ˍ
|
|
|
Treatment
|
|
◽
|
Andrews DW, Scott CB, Sperduto PW,
Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J,
Bahary JP, Souhami L, Rotman M, Mehta MP, Curran WJ Jr.
Whole
brain radiation therapy with or without stereotactic radiosurgery
boost for patients with one to three brain metastases: phase III
results of the RTOG 9508 randomised trial.
Lancet.
2004 May 22;363(9422):1665-72→.
doi: 10.1016/S0140-6736(04)16250-8→.
PMID: 15158627→.
Phase 3 trial. ˍ
|
|
|
◽
|
Aoyama H, Shirato H, Tago M,
Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura
H, Kunieda E, Inomata T, Hayakawa K, Katoh N, Kobashi
G.
Stereotactic
radiosurgery plus whole-brain radiation therapy vs stereotactic
radiosurgery alone for treatment of brain metastases: a randomized
controlled trial.
JAMA.
2006 Jun 7;295(21):2483-91→.
doi: 10.1001/jama.295.21.2483→.
PMID: 16757720→.
Prospective study. ˍ
|
|
|
◽
|
Aronen HJ, Gazit IE, Louis DN,
Buchbinder BR, Pardo FS, Weisskoff RM, Harsh GR, Cosgrove GR,
Halpern EF, Hochberg FH, et al.
Cerebral
blood volume maps of gliomas: comparison with tumor grade and
histologic findings.
Radiology.
1994 Apr 1;191(1):41-51→.
doi: 10.1148/radiology.191.1.8134596→.
PMID: 8134596→.
Retrospective analysis. ˍ
|
|
|
◽
|
Batchelor TT, Sorensen AG, di
Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen
PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis
DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK.
AZD2171,
a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor
vasculature and alleviates edema in glioblastoma patients.
Cancer
Cell. 2007 Jan 15;11(1):83-95→.
doi: 10.1016/j.ccr.2006.11.021
ˍ.
PMID: 17222792→.
Phase 2 trial. ˍ
|
|
|
◽
|
Brem H, Piantadosi S, Burger PC,
Walker M, Selker R, Vick NA, Black K, Sisti M, Brem S, Mohr G,
Muller P, Morawetz R, Schold SC.
Placebo-controlled
trial of safety and efficacy of intraoperative controlled delivery
by biodegradable polymers of chemotherapy for recurrent gliomas.
The Polymer-brain Tumor Treatment Group.
Lancet.
1995 Apr 22;345(8956):1008-12→.
doi: 10.1016/s0140-6736(95)90755-6→.
PMID: 7723496→.
Prospective study. ˍ
|
|
|
◽
|
Burger PC, Vogel FS, Green SB,
Strike TA.
Glioblastoma
multiforme and anaplastic astrocytoma. Pathologic criteria and
prognostic implications.
Cancer.
1985 Sep 1;56(5):1106-11→.
doi:
10.1002/1097-0142(19850901)56:5<1106::aid-cncr2820560525>3.0.co;2-2→.
PMID: 2990664→.
Retrospective analysis. ˍ
|
|
|
◽
|
Cairncross JG, Ueki K, Zlatescu MC,
Lisle DK, Finkelstein DM, Hammond RR, Silver JS, Stark PC,
Macdonald DR, Ino Y, Ramsay DA, Louis DN.
Specific
genetic predictors of chemotherapeutic response and survival in
patients with anaplastic oligodendrogliomas.
J
Natl Cancer Inst. 1998 Oct 7;90(19):1473-9→.
doi: 10.1093/jnci/90.19.1473→.
PMID: 9776413→.
Retrospective analysis. ˍ
|
|
|
◽
|
Chang EL, Wefel JS, Hess KR, Allen
PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH,
Meyers CA.
Neurocognition
in patients with brain metastases treated with radiosurgery or
radiosurgery plus whole-brain irradiation: a randomised controlled
trial.
Lancet
Oncol. 2009 Oct 5;10(11):1037-44→.
doi: 10.1016/S1470-2045(09)70263-3→.
PMID: 19801201→.
Prospective study. ˍ
|
|
|
◽
|
Culver KW, Ram Z, Wallbridge S,
Ishii H, Oldfield EH, Blaese RM.
In
vivo gene transfer with retroviral vector-producer cells for
treatment of experimental brain tumors.
Science.
1992 Jun 12;256(5063):1550-2→.
doi: 10.1126/science.1317968→.
PMID: 1317968→.
Laboratory investigation. ˍ
|
|
|
◽
|
Curran WJ Jr, Scott CB, Horton J,
Nelson JS, Weinstein AS, Fischbach AJ, Chang CH, Rotman M, Asbell
SO, Krisch RE, et al.
Recursive
partitioning analysis of prognostic factors in three Radiation
Therapy Oncology Group malignant glioma trials.
J
Natl Cancer Inst. 1993 May 5;85(9):704-10→.
doi: 10.1093/jnci/85.9.704→.
PMID: 8478956→.
Recursive partitioning analysis. ˍ
|
|
|
◽
|
Di Chiro G, DeLaPaz RL, Brooks RA,
Sokoloff L, Kornblith PL, Smith BH, Patronas NJ, Kufta CV, Kessler
RM, Johnston GS, Manning RG, Wolf AP.
Glucose
utilization of cerebral gliomas measured by [18F]
fluorodeoxyglucose and positron emission tomography.
Neurology.
1982 Dec 1;32(12):1323-9→.
doi: 10.1212/wnl.32.12.1323→.
PMID: 6983044→.
Prospective study; ˍ
|
|
|
◽
|
Esteller M, Garcia-Foncillas J,
Andion E, Goodman SN, Hidalgo OF, Vanaclocha V, Baylin SB, Herman
JG.
Inactivation
of the DNA-repair gene MGMT and the clinical response of gliomas
to alkylating agents.
N
Engl J Med. 2000 Nov 9;343(19):1350-4→.
doi: 10.1056/NEJM200011093431901→.
PMID: 11070098→.
Prospective study. ˍ
Erratum in: N Engl J Med 2000
Dec 7;343(23):1740→.
doi: 10.1056/NEJM200012073432320→.
Correction. ˍ
|
|
|
◽
|
Fine HA, Dear KB, Loeffler JS,
Black PM, Canellos GP.
Meta-analysis
of radiation therapy with and without adjuvant chemotherapy for
malignant gliomas in adults.
Cancer.
1993 Apr 15;71(8):2585-97→.
doi:
10.1002/1097-0142(19930415)71:8<2585::aid-cncr2820710825>3.0.co;2-s→.
PMID: 8453582→.
Meta-analysis. ˍ
|
|
|
◽
|
Friedman HS, Prados MD, Wen PY,
Mikkelsen T, Schiff D, Abrey LE, Yung WK, Paleologos N, Nicholas
MK, Jensen R, Vredenburgh J, Huang J, Zheng M, Cloughesy T.
Bevacizumab
alone and in combination with irinotecan in recurrent
glioblastoma.
J
Clin Oncol. 2009 Aug 31;27(28):4733-40→.
doi: 10.1200/JCO.2008.19.8721→.
PMID: 19720927→.
Phase 2 trial. ˍ
|
|
|
◽
|
Gaspar L, Scott C, Rotman M, Asbell
S, Phillips T, Wasserman T, McKenna WG, Byhardt R.
Recursive
partitioning analysis (RPA) of prognostic factors in three
Radiation Therapy Oncology Group (RTOG) brain metastases
trials.
Int J
Radiat Oncol Biol Phys. 1997 Mar 1;37(4):745-51→.
doi: 10.1016/s0360-3016(96)00619-0→.
PMID: 9128946→.
Retrospective analysis. ˍ
|
|
|
◽
|
Gilbert RW, Kim JH, Posner JB.
Epidural
spinal cord compression from metastatic tumor: diagnosis and
treatment.
Ann
Neurol. 1978 Jan;3(1):40-51→.
doi: 10.1002/ana.410030107→.
PMID: 655653→.
Retrospective analysis. ˍ
|
|
|
◽
|
Hegi ME, Diserens AC, Gorlia T,
Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason
W, Mariani L, Bromberg JE, Hau P, Mirimanoff RO, Cairncross JG,
Janzer RC, Stupp R.
MGMT
gene silencing and benefit from temozolomide in glioblastoma.
N
Engl J Med. 2005 Mar 10;352(10):997-1003→.
doi: 10.1056/NEJMoa043331→.
PMID: 15758010→.
Clinical trial. ˍ
|
|
|
◽
|
Hochberg FH, Pruitt A.
Assumptions
in the radiotherapy of glioblastoma.
Neurology.
1980 Sep 1;30(9):907-11→.
doi: 10.1212/wnl.30.9.907→.
PMID: 6252514→.
Retrospective analysis. ˍ
|
|
|
◽
|
Kreisl TN, Kim L, Moore K, Duic P,
Royce C, Stroud I, Garren N, Mackey M, Butman JA, Camphausen K,
Park J, Albert PS, Fine HA.
Phase
II trial of single-agent bevacizumab followed by bevacizumab plus
irinotecan at tumor progression in recurrent glioblastoma.
J
Clin Oncol. 2008 Dec 29. 2009;27(5):740-5→.
doi: 10.1200/JCO.2008.16.3055→.
PMID: 19114704→.
Phase 2 trial. ˍ
|
|
|
◽
|
Lacroix M, Abi-Said D, Fourney DR,
Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch
SJ, Holland E, Hess K, Michael C, Miller D, Sawaya R.
A
multivariate analysis of 416 patients with glioblastoma
multiforme: prognosis, extent of resection, and survival.
J
Neurosurg. 2001 Aug;95(2):190-8→.
doi: 10.3171/jns.2001.95.2.0190→.
PMID: 11780887→.
Retrospective analysis. ˍ
|
|
|
◽
|
Markert JM, Medlock MD, Rabkin SD,
Gillespie GY, Todo T, Hunter WD, Palmer CA, Feigenbaum F,
Tornatore C, Tufaro F, Martuza RL.
Conditionally
replicating herpes simplex virus mutant, G207 for the treatment of
malignant glioma: results of a phase I trial
Gene
Ther. 2000 May 25;7(10):867-74→.
doi: 10.1038/sj.gt.3301205→.
PMID: 10845725→.
Phase 1 trial. ˍ
|
|
|
◽
|
Mellinghoff IK, Wang MY, Vivanco I,
Haas-Kogan DA, Zhu S, Dia EQ, Lu KV, Yoshimoto K, Huang JH, Chute
DJ, Riggs BL, Horvath S, Liau LM, Cavenee WK, Rao PN, Beroukhim R,
Peck TC, Lee JC, Sellers WR, Stokoe D, Prados M, Cloughesy TF,
Sawyers CL, Mischel PS.
Molecular
determinants of the response of glioblastomas to EGFR kinase
inhibitors.
N
Engl J Med. 2005 Nov 10;353(19):2012-24→.
doi: 10.1056/NEJMoa051918→.
PMID: 16282176→.
Clinical study. ˍ
Erratum in: N Engl J Med.
2006 Feb 23;354(8):884→.
doi: 10.1056/NEJMx060009→.
Correction. ˍ
|
|
|
◽
|
Millauer B, Shawver LK, Plate KH,
Risau W, Ullrich A.
Glioblastoma
growth inhibited in vivo by a dominant-negative Flk-1
mutant.
Nature.
1994 Feb 10;367(6463):576-9→.
doi: 10.1038/367576a0→.
PMID: 8107827→.
Laboratory investigation. ˍ
|
|
|
◽
|
Mirimanoff RO, Dosoretz DE,
Linggood RM, Ojemann RG, Martuza RL.
Meningioma:
analysis of recurrence and progression following neurosurgical
resection.
J
Neurosurg. 1985 Jan;62(1):18-24→.
doi: 10.3171/jns.1985.62.1.0018→.
PMID: 3964853→.
Retrospective analysis. ˍ
|
|
|
◽
|
Ohgaki H, Kleihues P.
Population-based
studies on incidence, survival rates, and genetic alterations in
astrocytic and oligodendroglial gliomas.
J
Neuropathol Exp Neurol. 2005 Jun 1;64(6):479-89→.
doi: 10.1093/jnen/64.6.479→.
PMID: 15977639→.
Retrospective analysis & Review. ˍ
|
|
|
◽
|
Ohgaki H, Dessen P, Jourde B,
Horstmann S, Nishikawa T, Di Patre PL, Burkhard C, Schüler D,
Probst-Hensch NM, Maiorka PC, Baeza N, Pisani P, Yonekawa Y,
Yasargil MG, Lütolf UM, Kleihues P.
Genetic
pathways to glioblastoma: a population-based study.
Cancer
Res. 2004 Oct 1;64(19):6892-9→.
doi: 10.1158/0008-5472.CAN-04-1337→.
PMID: 15466178→.
Retrospective analysis. ˍ
|
|
|
◽
|
Patchell RA, Tibbs PA, Regine WF,
Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B.
Direct
decompressive surgical resection in the treatment of spinal cord
compression caused by metastatic cancer: a randomised
trial.
Lancet.
2005 Jul 21;366(9486):643-8→.
doi: 10.1016/S0140-6736(05)66954-1→.
PMID: 16112300→.
Prospective study. ˍ
|
|
|
◽
|
Patchell RA, Tibbs PA, Regine WF,
Dempsey RJ, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young
B.
Postoperative radiotherapy in the treatment of single
metastases to the brain: a randomized trial.
JAMA. 1998 Nov
4;280(17):1485-9→.
doi: 10.1001/jama.280.17.1485→.
PMID: 9809728→.
Prospective study. ˍ
|
|
|
◽
|
Patchell RA, Tibbs PA, Walsh JW,
Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS,
Young B.
A
randomized trial of surgery in the treatment of single metastases
to the brain.
N
Engl J Med. 1990 Feb 22;322(8):494-500→.
doi: 10.1056/NEJM199002223220802→.
PMID: 2405271→.
Prospective study. ˍ
|
|
|
◽
|
Pearce MS, Salotti JA, Little MP,
McHugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Sir
Craft AW, Parker L, Berrington de González A.
Radiation
exposure from CT scans in childhood and subsequent risk of
leukaemia and brain tumours: a retrospective cohort study.
Lancet.
2012 Jun 7;380(9840):499-505→.
doi: 10.1016/S0140-6736(12)60815-0→.
PMID: 22681860→.
Retrospective analysis. ˍ
|
|
|
◽
|
Ron E, Modan B, Boice JD Jr,
Alfandary E, Stovall M, Chetrit A, Katz L.
Tumors
of the brain and nervous system after radiotherapy in childhood.
N
Engl J Med. 1988 Oct 20;319(16):1033-9→.
doi: 10.1056/NEJM198810203191601→.
PMID: 3173432→.
Retrospective analysis. ˍ
|
|
|
◽
|
Simpson D.
The
recurrence of intracranial meningiomas after surgical treatment.
J
Neurol Neurosurg Psychiatry. 1957 Feb;20(1):22-39→.
doi: 10.1136/jnnp.20.1.22→.
PMID: 13406590→.
Retrospective analysis. ˍ
Erratum in: J Neurol
Neurosurg Psychiatry. 1957 May;13(2):155→.
Correction. ˍ
Erratum in: J Neurol
Neurosurg Psychiatry. 1957 Aug;20(3):240→.
Correction. ˍ
|
|
|
◽
|
Smith JS, Perry A, Borell TJ, Lee
HK, O'Fallon J, Hosek SM, Kimmel D, Yates A, Burger PC,
Scheithauer BW, Jenkins RB.
Alterations
of chromosome arms 1p and 19q as predictors of survival in
oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas.
J
Clin Oncol. 2000 Feb 1;18(3):636-45→.
doi: 10.1200/JCO.2000.18.3.636→.
PMID: 10653879→.
Laboratory investigation. ˍ
|
|
|
◽
|
Stummer W, Pichlmeier U, Meinel T,
Wiestler OD, Zanella F, Reulen HJ; ALA-Glioma Study Group.
Fluorescence-guided
surgery with 5-aminolevulinic acid for resection of malignant
glioma: a randomised controlled multicentre phase III
trial.
Lancet
Oncol. 2006 Apr 13;7(5):392-401→.
doi: 10.1016/S1470-2045(06)70665-9→.
PMID: 16648043→.
Phase
3 trial. ˍ
|
|
|
◽
|
Stupp
R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC,
Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA,
Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa
S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross JG,
Mirimanoff RO; European Organisation for Research and Treatment of
Cancer Brain Tumour and Radiation Oncology Groups; National Cancer
Institute of Canada Clinical Trials Group.
Effects
of radiotherapy with concomitant and adjuvant temozolomide versus
radiotherapy alone on survival in glioblastoma in a randomised
phase III study: 5-year analysis of the EORTC-NCIC trial.
Lancet
Oncol. 2009 Mar 9. 2009;10(5):459-66→.
doi: 10.1016/S1470-2045(09)70025-7→.
PMID: 19269895→.
Phase 3 trial. ˍ
|
|
|
◽
|
Stupp R, Mason WP, van den Bent MJ,
Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C,
Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier
A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO; European
Organisation for Research and Treatment of Cancer Brain Tumor and
Radiotherapy Groups; National Cancer Institute of Canada Clinical
Trials Group.
Radiotherapy
plus concomitant and adjuvant temozolomide for glioblastoma.
N
Engl J Med. 2005 Mar 10;352(10):987-96→.
doi: 10.1056/NEJMoa043330→.
PMID: 15758009→.
Phase 3 trial. ˍ
|
|
|
◽
|
Sugahara T, Korogi Y, Kochi M,
Ikushima I, Shigematu Y, Hirai T, Okuda T, Liang L, Ge Y, Komohara
Y, Ushio Y, Takahashi M.
Usefulness
of diffusion-weighted MRI with echo-planar technique in the
evaluation of cellularity in gliomas.
J
Magn Reson Imaging. 1999 Jan;9(1):53-60→.
doi: 10.1002/(sici)1522-2586(199901)9:1<53::aid-jmri7>3.0.co;2-2→.
PMID: 10030650→.
Prospective study. ˍ
|
|
|
◽
|
Vredenburgh JJ, Desjardins A,
Herndon JE 2nd, Marcello J, Reardon DA, Quinn JA, Rich JN,
Sathornsumetee S, Gururangan S, Sampson J, Wagner M, Bailey L,
Bigner DD, Friedman AH, Friedman HS.
Bevacizumab
plus irinotecan in recurrent glioblastoma multiforme.
J
Clin Oncol. 2007 Oct 20;25(30):4722-9→.
doi: 10.1200/JCO.2007.12.2440→.
PMID: 17947719→.
Phase 2 trial. ˍ
|
|
|
◽
|
Vredenburgh JJ, Desjardins A,
Herndon JE 2nd, Dowell JM, Reardon DA, Quinn JA, Rich JN,
Sathornsumetee S, Gururangan S, Wagner M, Bigner DD, Friedman AH,
Friedman HS.
Phase
II trial of bevacizumab and irinotecan in recurrent malignant
glioma.
Clin
Cancer Res. 2007 Feb 15;13(4):1253-9→.
doi: 10.1158/1078-0432.CCR-06-2309→.
PMID: 17317837→.
Phase 2 trial. ˍ
|
|
|
◽
|
Walker MD, Green SB, Byar DP,
Alexander E Jr, Batzdorf U, Brooks WH, Hunt WE, MacCarty CS,
Mahaley MS Jr, Mealey J Jr, Owens G, Ransohoff J 2nd, Robertson
JT, Shapiro WR, Smith KR Jr, Wilson CB, Strike TA.
Randomized
comparisons of radiotherapy and nitrosoureas for the treatment of
malignant glioma after surgery.
N
Engl J Med. 1980 Dec 4;303(23):1323-9→.
doi: 10.1056/NEJM198012043032303→.
PMID: 7001230→.
Prospective study. ˍ
|
|
|
◽
|
Walker MD, Alexander E Jr, Hunt WE,
MacCarty CS, Mahaley MS Jr, Mealey J Jr, Norrell HA, Owens G,
Ransohoff J, Wilson CB, Gehan EA, Strike TA.
Evaluation
of BCNU and/or radiotherapy in the treatment of anaplastic
gliomas. A cooperative clinical trial.
J
Neurosurg. 1978 Sep;49(3):333-43→.
doi: 10.3171/jns.1978.49.3.0333→.
PMID: 355604→.
Prospective study. ˍ
|
|
|
◽
|
Wasserstrom WR, Glass JP, Posner
JB.
Diagnosis
and treatment of leptomeningeal metastases from solid tumors:
experience with 90 patients.
Cancer.
1982 Feb 15;49(4):759-72→.
doi:
10.1002/1097-0142(19820215)49:4<759::aid-cncr2820490427>3.0.co;2-7→.
PMID: 6895713→.
Retrospective study. ˍ
|
|
|
◽
|
Westphal M, Hilt DC, Bortey E,
Delavault P, Olivares R, Warnke PC, Whittle IR, Jääskeläinen
J, Ram Z.
A
phase 3 trial of local chemotherapy with biodegradable carmustine
(BCNU) wafers (Gliadel wafers) in patients with primary malignant
glioma.
Neuro
Oncol. 2003 Apr 1;5(2):79-88→.
doi: 10.1093/neuonc/5.2.79→.
PMID: 12672279→.
Phase 3 trial. ˍ
|
|
|
◽
|
Wong ET, Hess KR, Gleason MJ,
Jaeckle KA, Kyritsis AP, Prados MD, Levin VA, Yung WK.
Outcomes
and prognostic factors in recurrent glioma patients enrolled onto
phase II clinical trials.
J
Clin Oncol. 1999 Aug 1;17(8):2572-8→.
doi: 10.1200/JCO.1999.17.8.2572→.
PMID: 10561324→.
Phase 2 trial. ˍ
|
|
|
◽
|
Yung WK, Albright RE, Olson J,
Fredericks R, Fink K, Prados MD, Brada M, Spence A, Hohl RJ,
Shapiro W, Glantz M, Greenberg H, Selker RG, Vick NA, Rampling R,
Friedman H, Phillips P, Bruner J, Yue N, Osoba D, Zaknoen S, Levin
VA.
A
phase II study of temozolomide vs. procarbazine in patients with
glioblastoma multiforme at first relapse.
Br
J Cancer. 2000 Aug 8;83(5):588-93→.
doi: 10.1054/bjoc.2000.1316→.
PMID: 10944597→.
Phase 2 trial. ˍ
|
|
|
|
|
|
|
|
|