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CNS Tumors | Etiopathogenesis | Extracellular Vesicles

They can be divided into three types: exosomes, the smallest vesicles that are released from inside the cell and follow the endosomal pathway; microvesicles, which are always released from inside the cell, but are produced using the cell membrane itself which incorporates the load to be transported and “buds” outwards; and apoptotic bodies, characteristic of dying cells. The latter are less studied in the application field, which is why they are not discussed in this analysis. Exosomes and microvesicles are very different from each other but have common characteristics in terms of size and content: both transport RNA, proteins and lipids, underlining their involvement in the regulation, through different molecular mechanisms, of various biological functions.

Home > Publications > Topics > CNS Tumors > Etiopathogenesis > Extracellular Vesicles

Wijaya W, Phyu SM, Jiang S.
Extracellular Vesicle (EV) Survivin for Cancer Diagnostics and Therapeutics: A Review.
Front Biosci (Landmark Ed). 2024 Aug 22;29(8):302. doi: 10.31083/j.fbl2908302. PMID: 39206911. Review. ˍ

Zhang X, Artz N, Steindler DA, Hingtgen S, Satterlee AB.
Exosomes: Traversing the blood-brain barrier and their therapeutic potential in brain cancer.
Biochim Biophys Acta Rev Cancer. 2025 Mar 15;1880(3):189300. doi: 10.1016/j.bbcan.2025.189300. PMID: 40097050. Review˰ ˍ