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*Silvani A, Franceschi E.
A
new era after a long wait: Vorasidenib, an inhibitor of mutant
IDH1 and IDH2 enzymes in patients with IDH-mutant glioma.
Tumori.
2024 Jan 2:3008916231217583. doi:
10.1177/03008916231217583. PMID:
38166539. Editorial. ˍ
Related
article:
Mellinghoff
IK, van den Bent MJ, Blumenthal DT, et al.
Vorasidenib
in IDH1- or IDH2-Mutant Low-Grade Glioma.
N
Engl J Med.
2023 Jun 4. doi:
10.1056/NEJMoa2304194. PMID:
37272516. Interventional study. ˍ
*Geurts M, Preusser M.
Locoregional
delivery of CAR-T cells - breaking the spell in
glioblastoma?
Neuro
Oncol. 2024 Apr 9:noae063. doi:
10.1093/neuonc/noae063. PMID:
38592708. Editorial. ˍ
Lowenstein PR, Varela ML, Castro MG.
Three
recent breakthroughs in CAR T cells for the treatment of
glioblastoma: Is it the light at the end of the tunnel?
Mol
Ther. 2024 Apr 16:S1525-0016(24)00235-1. doi:
10.1016/j.ymthe.2024.04.018. PMID:
38631354. Comment˰ ˍ
Related
articles:
-Choi BD, Gerstner ER, Frigault
MJ, Leick MB, Mount CW, Balaj L, Nikiforow S, Carter BS, Curry WT,
Gallagher K, Maus MV.
Intraventricular
CARv3-TEAM-E T Cells in Recurrent Glioblastoma.
N
Engl J Med.
2024 Mar 13;390(14):1290-1298. doi:
10.1056/NEJMoa2314390. PMID:
38477966. Interventional study. ˍ
-Bagley SJ, Logun M, Fraietta
JA, Wang X, Desai AS, Bagley LJ, Nabavizadeh A, Jarocha D, Martins
R, Maloney E, Lledo L, Stein C, Marshall A, Leskowitz R, Jadlowsky
JK, Christensen S, Oner BS, Plesa G, Brennan A, Gonzalez V, Chen
F, Sun Y, Gladney W, Barrett D, Nasrallah MP, Hwang WT, Ming GL,
Song H, Siegel DL, June CH, Hexner EO, Binder ZA, O'Rourke
DM.
Intrathecal
bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent
glioblastoma: phase 1 trial interim results.
Nat
Med. 2024
Mar 13. doi:
10.1038/s41591-024-02893-z. PMID:
38480922. Interventional study˰ ˍ
-Brown CE, Hibbard JC, Alizadeh
D, Blanchard MS, Natri HM, Wang D, Ostberg JR, Aguilar B, Wagner
JR, Paul JA, Starr R, Wong RA, Chen W, Shulkin N, Aftabizadeh M,
Filippov A, Chaudhry A, Ressler JA, Kilpatrick J, Myers-McNamara
P, Chen M, Wang LD, Rockne RC, Georges J, Portnow J, Barish ME,
D'Apuzzo M, Banovich NE, Forman SJ, Badie B.
Locoregional
delivery of IL-13Rα2-targeting CAR-T cells in recurrent
high-grade glioma: a phase 1 trial.
Nat
Med. 2024
Mar 7. doi:
10.1038/s41591-024-02875-1. PMID:
38454126. Interventional study. ˍ
Lazarev S, Sindhu KK.
Vorasidenib: a
new hope or a false promise for patients with low-grade glioma?
Nat
Rev Clin Oncol. 2024 Sep 12. doi:
10.1038/s41571-024-00944-5. PMID:
39266767. Perspective˰
ˍ