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Diffuse midline glioma | Treatment | Clinical trials | CAR-T cells
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*Monje
M, Mahdi J, Majzner R, Yeom K, Schultz LM, Richards RM, Barsan V,
Song KW, Kamens J, Baggott C, Kunicki M, Lim AS, Reschke A,
Mavroukakis S, Egeler E, Moon J, Patel S, Chinnasamy H, Erickson
C, Jacobs A, Duh AK, Rietberg SP, Tunuguntla R, Klysz DD, Fowler
C, Green S, Beebe B, Carr C, Fujimoto M, Brown AK, Petersen AG,
McIntyre C, Siddiqui A, Lepori-Bui N, Villar K, Pham K, Bove R,
Musa E, Reynolds W, Kuo A, Prabhu S, Rasmussen L, Cornell TT,
Partap S, Fisher PG, Campen CJ, Grant G, Prolo L, Ye X, Sahaf B,
Davis KL, Feldman SA, Ramakrishna S, Mackall C.
Sequential
intravenous and intracerebroventricular GD2-CAR T-cell therapy for
H3K27M-mutated diffuse midline gliomas.
medRxiv
[Preprint]. 2024 Jun 27:2024.06.25.24309146. doi:
10.1101/2024.06.25.24309146. PMID:
38978673. Interventional study. ˍ
Vitanza NA, Ronsley R, Choe M, Seidel K, Huang W, Rawlings-Rhea
SD, Beam M, Steinmetzer L, Wilson AL, Brown C, Beebe A, Lindgren
C, Gustafson JA, Wein A, Holtzclaw S, Hoeppner C, Goldstein HE,
Browd SR, Hauptman JS, Lee A, Ojemann JG, Crotty EE, Leary SES,
Perez FA, Wright JN, Alonso MM, Dun MD, Foster JB, Hurst D, Kong
A, Thomsen A, Orentas RJ, Albert CM, Pinto N, Annesley C, Gardner
RA, Ho O, Pattabhi S, Gust J, Wendler JP, Park JR, Jensen MC.
Intracerebroventricular
B7-H3-targeting CAR T cells for
diffuse intrinsic pontine glioma: a phase 1
trial.
Nat
Med. 2025 Jan 7. doi:
10.1038/s41591-024-03451-3. PMID:
39775044. Interventional study. ˍ