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Diffuse midline glioma | Treatment | Immunotherapy | CAR-T cells
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*Monje
M, Mahdi J, Majzner R, Yeom K, Schultz LM, Richards RM, Barsan V,
Song KW, Kamens J, Baggott C, Kunicki M, Lim AS, Reschke A,
Mavroukakis S, Egeler E, Moon J, Patel S, Chinnasamy H, Erickson
C, Jacobs A, Duh AK, Rietberg SP, Tunuguntla R, Klysz DD, Fowler
C, Green S, Beebe B, Carr C, Fujimoto M, Brown AK, Petersen AG,
McIntyre C, Siddiqui A, Lepori-Bui N, Villar K, Pham K, Bove R,
Musa E, Reynolds W, Kuo A, Prabhu S, Rasmussen L, Cornell TT,
Partap S, Fisher PG, Campen CJ, Grant G, Prolo L, Ye X, Sahaf B,
Davis KL, Feldman SA, Ramakrishna S, Mackall C.
Sequential
intravenous and intracerebroventricular GD2-CAR T-cell therapy for
H3K27M-mutated diffuse midline gliomas.
medRxiv
[Preprint].
2024 Jun 27:2024.06.25.24309146. doi:
10.1101/2024.06.25.24309146. PMID:
38978673. Interventional study. ˍ
*Ledford H.
This kids' brain cancer is
incurable - but immune therapy holds promise.
Nature.
2024 Jul 12. doi:
10.1038/d41586-024-02255-2. PMID:
38997564. News. ˍ
Power
EA, Millesi E, Rechberger JS, Daniels DJ.
CAR-T
cells for H3K27-altered diffuse midline gliomas: where do we
stand?
Immunotherapy.
2024 Jul 17:1-4. doi:
10.1080/1750743X.2024.2373043. PMID:
39016046. Editorial˰ ˍ
Monje M, Mahdi J, Majzner R, Yeom KW, Schultz LM, Richards RM,
Barsan V, Song KW, Kamens J, Baggott C, Kunicki M, Rietberg SP,
Lim AS, Reschke A, Mavroukakis S, Egeler E, Moon J, Patel S,
Chinnasamy H, Erickson C, Jacobs A, Duh AK, Tunuguntla R, Klysz
DD, Fowler C, Green S, Beebe B, Carr C, Fujimoto M, Brown AK,
Petersen AG, McIntyre C, Siddiqui A, Lepori-Bui N, Villar K, Pham
K, Bove R, Musa E, Reynolds WD, Kuo A, Prabhu S, Rasmussen L,
Cornell TT, Partap S, Fisher PG, Campen CJ, Grant G, Prolo L, Ye
X, Sahaf B, Davis KL, Feldman SA, Ramakrishna S, Mackall C.
Intravenous and intracranial GD2-CAR T
cells for H3K27M+
diffuse midline gliomas.
Nature.
2024 Nov 13. doi:
10.1038/s41586-024-08171-9. PMID:
39537919. Interventional study.
ˍ
Tykocki T.
Diffuse intrinsic pontine
glioma and CAR-T therapy: An Emerging Frontier.
World
Neurosurg. 2024 Dec 16:123579? doi: 10.1016/j.wneu.2024.123579?
PMID:
39694135. Review˰ ˍ
Vitanza NA, Ronsley R, Choe M, Seidel K, Huang W, Rawlings-Rhea
SD, Beam M, Steinmetzer L, Wilson AL, Brown C, Beebe A, Lindgren
C, Gustafson JA, Wein A, Holtzclaw S, Hoeppner C, Goldstein HE,
Browd SR, Hauptman JS, Lee A, Ojemann JG, Crotty EE, Leary SES,
Perez FA, Wright JN, Alonso MM, Dun MD, Foster JB, Hurst D, Kong
A, Thomsen A, Orentas RJ, Albert CM, Pinto N, Annesley C, Gardner
RA, Ho O, Pattabhi S, Gust J, Wendler JP, Park JR, Jensen MC.
Intracerebroventricular
B7-H3-targeting CAR T cells for
diffuse intrinsic pontine glioma: a phase 1
trial.
Nat
Med. 2025 Jan 7. doi:
10.1038/s41591-024-03451-3. PMID:
39775044. Interventional study. ˍ