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Glioblastoma | Etiopathogenesis | Extracellular vesicles
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They can be divided into three types: exosomes, the smallest vesicles that are released from inside the cell and follow the endosomal pathway; microvesicles, which are always released from inside the cell, but are produced using the cell membrane itself which incorporates the load to be transported and “buds” outwards; and apoptotic bodies, characteristic of dying cells. The latter are less studied in the application field, which is why they are not discussed in this analysis. Exosomes and microvesicles are very different from each other but have common characteristics in terms of size and content: both transport RNA, proteins and lipids, underlining their involvement in the regulation, through different molecular mechanisms, of various biological functions.
*Castellani G, Buccarelli M, D'Alessandris QG, Ilari R, Cappannini
A, Pedini F, Boe A, Lulli V, Parolini I, Giannetti S, Biffoni M,
Zappavigna V, Marziali G, Pallini R, Ricci-Vitiani
L.
Extracellular vesicles produced by
irradiated endothelial or Glioblastoma stem cells promote tumor
growth and vascularization modulating tumor
microenvironment.
Cancer
Cell Int. 2024 Feb 12;24(1):72. doi:
10.1186/s12935-024-03253-0. PMID:
38347567. Laboratory
investigation.
ˍ
Wang L, Wang W, Hu D, Liang Y, Liu Z, Zhong T, Wang
X.
Tumor-derived extracellular vesicles
regulate macrophage polarization: role and therapeutic
perspectives.
Front
Immunol. 2024 Apr 16;15:1346587. doi:
10.3389/fimmu.2024.1346587. PMID:
38690261. Review. ˍ
Schiera G, Di Liegro CM, Vento F, Di Liegro I.
Role
of Extracellular Vesicles in the Progression of Brain Tumors.
Biology
(Basel). 2024 Aug 2;13(8):586. doi:
10.3390/biology13080586. PMID:
39194524. Review. ˍ
Ghazi B, Harmak Z, Rghioui M, Kone AS, El Ghanmi A, Badou A.
Decoding the secret of extracellular
vesicles in the immune tumor microenvironment of the glioblastoma:
on the border of kingdoms.
Front
Immunol. 2024 Aug 29;15:1423232. doi:
10.3389/fimmu.2024.1423232. PMID:
39267734. Review. ˍ
Giuliani P, De Simone C, Febo G, Bellasame A, Tupone N, Di Virglio
V, di Giuseppe F, Ciccarelli R, Di Iorio P, Angelucci S.
Proteomics Studies on Extracellular
Vesicles Derived from Glioblastoma: Where Do We Stand?
Int
J Mol Sci. 2024 Sep 10;25(18):9778. doi:
10.3390/ijms25189778. PMID:
39337267. Review. ˍ
Beylerli O, Gareev I, Ilyasova T, Musaev E, Chekhonin V.
The
Mechanism of Action of Exosomes Derived from Glioblastoma Cells.
Curr
Med Chem. 2024 Nov 4. doi:
10.2174/0109298673344390241017065119. PMID:
39501957. Review˰ ˍ
Hallal SM, Sida LA, Tűzesi CÁ, Shivalingam B, Sim HW,
Buckland ME, Satgunaseelan L, Alexander KL.
Size
matters: Biomolecular compositions of small and large
extracellular vesicles in the urine of glioblastoma patients.
J
Extracell Biol. 2024 Nov 15;3(11):e70021. doi:
10.1002/jex2.70021. PMID:
39554867. Laboratory investigation. ˍ
Agosti E, Antonietti S, Ius T, Fontanella MM, Zeppieri M, Panciani
PP.
A Systematic Review of Mesenchymal
Stem Cell-Derived Extracellular Vesicles: A Potential Treatment
for Glioblastoma.
Brain
Sci. 2024 Oct 25;14(11):1058. doi:
10.3390/brainsci14111058. PMID:
39595821. Review. ˍ
Invasion of Glioblastoma Cells
*Lyukmanova EN, Kirichenko AV, Medyanik IA, Yashin KS,
Kirpichnikov MP, Bychkov ML.
Extracellular
Vesicles from Plasma of Patients with Glioblastoma Promote
Invasion of Glioblastoma Cells Even After Tumor Resection.
Biomedicines.
2024 Dec 13;12(12):2834. doi:
10.3390/biomedicines12122834. PMID:
39767739. Laboratory investigation. ˍ
Invasion of Glioblastoma Cells
Tamborini M, Ribecco V, Stanzani E, Sironi A, Tambalo M, Franzone
D, Florio E, Fraviga E, Saulle C, Gagliani MC, Pizzocri M,
Mattioli M, Cortese K, Jiang JX, Martano G, Politi LS, Riva M,
Pessina F, Pozzi D, Lodato S, Passoni L, Matteoli M.
Extracellular Vesicles Released by
Glioblastoma Cancer Cells Drive Tumor Invasiveness via Connexin-43
Gap Junctions.
Neuro
Oncol. 2025 Jan 30:noaf013. doi:
10.1093/neuonc/noaf013. PMID:
39883079. Laboratory investigation.
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