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Glioblastoma | Etiopathogenesis | Recurrence

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Tsuchiya T, Kawauchi D, Ohno M, Miyakita Y, Takahashi M, Yanagisawa S, Osawa S, Fujita S, Omura T, Narita Y.
Risk Factors of Distant Recurrence and Dissemination of IDH Wild-Type Glioblastoma: A Single-Center Study and Meta-Analysis. Cancers (Basel). 2024 Aug 18;16(16):2873. doi: 10.3390/cancers16162873. PMID: 39199644. Observational study; Meta-analysis. ˍ

Xie XP, Ganbold M, Li J, Lien M, Chipman ME, Wang T, Jayewickreme CD, Pedraza AM, Bale T, Tabar V, Brennan C, Sun D, Sharma R, Parada LF.
Glioblastoma functional heterogeneity and enrichment of cancer stem cells with tumor recurrence.
Neuron. 2024 Nov 6:S0896-6273(24)00733-5. doi: 10.1016/j.neuron.2024.10.012. PMID: 39510072. Laboratory investigation˰ ˍ

Mengüç Emir S, Karaoğlan BS, Kaşmer R, Şirin HB, Sarıyıldız B, Karakaş N.
Hunting glioblastoma recurrence: glioma stem cells as retrospective targets.
Am J Physiol Cell Physiol. 2025 Jan 16. doi: 10.1152/ajpcell.00344.2024. PMID: 39818986. Review˰ ˍ

Neural stem cells in the subventricular zone

*Li X, Kim HJ, Yoo J, Lee Y, Nam CH, Park J, Lee ST, Kim TM, Choi SH, Won JK, Park SH, Ju YS, Park JB, Kim SH, Chang JH, Wu HG, Park CK, Lee JH, Kang SG, Lee JH.
Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection.
Mol Cancer. 2025 Mar 4;24(1):64. doi: 10.1186/s12943-025-02273-2. PMID: 40033380. Laboratory investigation. ˍ

Malignant Cells Beyond the Tumor Core

Zhou Y, He Q, Huang G, Ouyang P, Wang H, Deng J, Chen P, Liang X, Hong Z, Zhang X, Qi S, Li Y.
Malignant Cells Beyond the Tumor Core: The Non-Negligible Factor to Overcome the Refractory of Glioblastoma.
CNS Neurosci Ther. 2025 Mar 19;31(3):e70333. doi: 10.1111/cns.70333. PMID: 40104956. Review. ˍ