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Mellinghoff IK, van den Bent MJ, Blumenthal DT, Touat M, Peters KB, Clarke J, Mendez J, Yust-Katz S, Welsh L, Mason WP, Ducray F, Umemura Y, Nabors B, Holdhoff M, Hottinger AF, Arakawa Y, Sepulveda JM, Wick W, Soffietti R, Perry JR, Giglio P, de la Fuente M, Maher EA, Schoenfeld S, Zhao D, Pandya SS, Steelman L, Hassan I, Wen PY, Cloughesy TF.
Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma.
N Engl J Med. 2023 Jun 4. doi: 10.1056/NEJMoa2304194. PMID: 37272516. Interventional study. ˍ




*Silvani A, Franceschi E.
A new era after a long wait: Vorasetinib, an inhibitor of mutant IDH1 and IDH2 enzymes in patients with IDH-mutant glioma.
Tumori. 2024 Jan 2:3008916231217583. doi: 10.1177/03008916231217583. PMID: 38166539. Editorial. ˍ
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Mellinghoff IK, van den Bent MJ, Blumenthal DT, et al.
Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma.
N Engl J Med. 2023 Jun 4. doi: 10.1056/NEJMoa2304194. PMID: 37272516. Interventional study. ˍ




Gatto L, Di Nunno V, Tosoni A, Bartolini S, Ranieri L, Franceschi E.
Vorasidenib in IDH1/2-mutant low-grade glioma: the grey zone of patient's selection.
Front Oncol. 2024 Jan 11;13:1339266. doi: 10.3389/fonc.2023.1339266. PMID: 38273856. Comment. ˍ
RELATED ARTICLE
Mellinghoff IK, van den Bent MJ, Blumenthal DT, Touat M, Peters KB, Clarke J, Mendez J, Yust-Katz S, Welsh L, Mason WP, Ducray F, Umemura Y, Nabors B, Holdhoff M, Hottinger AF, Arakawa Y, Sepulveda JM, Wick W, Soffietti R, Perry JR, Giglio P, de la Fuente M, Maher EA, Schoenfeld S, Zhao D, Pandya SS, Steelman L, Hassan I, Wen PY, Cloughesy TF.
Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma.
N Engl J Med. 2023 Jun 4. doi: 10.1056/NEJMoa2304194. PMID: 37272516. Interventional study. ˍ




Rudà R, Horbinski C, van den Bent M, Preusser M, Soffietti R.
IDH inhibition in gliomas: from preclinical models to clinical trials.
Nat Rev Neurol. 2024 May 17. doi: 10.1038/s41582-024-00967-7. PMID: 38760442. Review. ˍ




Aduwo JY, McClelland S 3rd.
Censoring Analysis of the INvestigating VorasiDenib In GliOma (INDIGO) Phase III Randomized Controlled Trial.
Am J Clin Oncol. 2025 Feb 14. doi: 10.1097/COC.0000000000001175. PMID: 39950862. Editorial. ˍ
RELATED ARTICLE
Mellinghoff IK, van den Bent MJ, Blumenthal DT, Touat M, Peters KB, Clarke J, Mendez J, Yust-Katz S, Welsh L, Mason WP, Ducray F, Umemura Y, Nabors B, Holdhoff M, Hottinger AF, Arakawa Y, Sepulveda JM, Wick W, Soffietti R, Perry JR, Giglio P, de la Fuente M, Maher EA, Schoenfeld S, Zhao D, Pandya SS, Steelman L, Hassan I, Wen PY, Cloughesy TF.
Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma.
N Engl J Med. 2023 Jun 4. doi: 10.1056/NEJMoa2304194. PMID: 37272516. Interventional study. ˍ