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Low-grade gliomas | Treatment | Targeted therapy | Tovorafenib
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van Tilburg CM, Kilburn LB, Perreault S, Schmidt R, Azizi AA,
Cruz-Martínez O, Zápotocký M, Scheinemann K,
Meeteren AYNS, Sehested A, Opocher E, Driever PH, Avula S, Ziegler
DS, Capper D, Koch A, Sahm F, Qiu J, Tsao LP, Blackman SC, Manley
P, Milde T, Witt R, Jones DTW, Hargrave D, Witt
O.
LOGGIC/FIREFLY-2: a phase 3,
randomized trial of tovorafenib vs. chemotherapy in pediatric and
young adult patients with newly diagnosed low-grade glioma
harboring an activating RAF alteration.
BMC
Cancer. 2024 Jan 30;24(1):147. doi:
10.1186/s12885-024-11820-x. PMID:
38291372. Interventional
study
protocol.
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